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ARO3 3-deoxy-7-phosphoheptulonate synthase ARO3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851605, updated on 23-Apr-2026
Official Symbol
ARO3
Official Full Name
3-deoxy-7-phosphoheptulonate synthase ARO3
Primary source
SGD:S000002442
Locus tag
YDR035W
See related
AllianceGenome:SGD:S000002442; FungiDB:YDR035W; VEuPathDB:YDR035W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 3-deoxy-7-phosphoheptulonate synthase activity. Predicted to be involved in aromatic amino acid family biosynthetic process. Predicted to act upstream of or within amino acid biosynthetic process. Located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See ARO3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (521816..522928)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Gln Neighboring gene cysteine-rich palmitoylated domain-containing protein CPP3 Neighboring gene mitochondrial 37S ribosomal protein mS47 EHD3 Neighboring gene lysine--tRNA ligase KRS1

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Purification and properties of the 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (phenylalanine-inhibitable) of Saccharomyces cerevisiae. Paravicini G, et al. Eur J Biochem, 1989 Dec 8. PMID 2574670
  2. Analysis of the structure and transcription of the aro3 cluster gene in Schizosaccharomyces pombe. Nakanishi N, et al. Mol Gen Genet, 1984. PMID 6092844
  3. Structure of the ARO3 gene of Saccharomyces cerevisiae. Paravicini G, et al. Mol Gen Genet, 1988 Sep. PMID 2906401
  4. A nonspecific inhibitory effect of tRNA on the activity of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Saccharomyces cerevisiae. Bell JB, et al. Biochim Biophys Acta, 1976 Jun 2. PMID 6062
  5. Evolution of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase-encoding genes in the yeast Saccharomyces cerevisiae. Helmstaedt K, et al. Proc Natl Acad Sci U S A, 2005 Jul 12. PMID 15987779, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-deoxy-7-phosphoheptulonate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-deoxy-7-phosphoheptulonate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-deoxy-7-phosphoheptulonate synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aromatic amino acid family biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aromatic amino acid family biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chorismate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chorismate biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleus HDA PubMed 
Preferred Names
3-deoxy-7-phosphoheptulonate synthase ARO3
NP_010320.3
  • 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    521816..522928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180343.3 → NP_010320.3  3-deoxy-7-phosphoheptulonate synthase ARO3

    See identical proteins and their annotated locations for NP_010320.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS23, P14843
    UniProtKB/TrEMBL
    A6ZY03, B3LGN0, B5VFT8, C7GQ13, C8Z4V7, G2WAE1
    Conserved Domains (1) summary
    TIGR00034
    Location:15 → 365
    aroFGH; phospho-2-dehydro-3-deoxyheptonate aldolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14843.1

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