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TRP1 phosphoribosylanthranilate isomerase TRP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851570, updated on 3-Jun-2026
Official Symbol
TRP1
Official Full Name
phosphoribosylanthranilate isomerase TRP1
Primary source
SGD:S000002414
Locus tag
YDR007W
See related
AllianceGenome:SGD:S000002414; FungiDB:YDR007W; VEuPathDB:YDR007W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphoribosylanthranilate isomerase activity. Involved in L-tryptophan biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See TRP1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (461842..462516)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene RNA polymerase III-inhibiting protein MAF1 Neighboring gene Sok1p Neighboring gene transcriptional regulator GAL3 Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A review of phenotypes in Saccharomyces cerevisiae. Hampsey M. Yeast, 1997 Sep 30. PMID 9301019
  2. Multiple control elements in the TRP1 promoter of Saccharomyces cerevisiae. Kim S, et al. Mol Cell Biol, 1986 Dec. PMID 3025648, Free PMC Article
  3. Cloning the Cryptococcus neoformans TRP1 gene by complementation in Saccharomyces cerevisiae. Perfect JR, et al. Gene, 1992 Dec 1. PMID 1452032
  4. Sequence of a yeast DNA fragment containing a chromosomal replicator and the TRP1 gene. Tschumper G, et al. Gene, 1980 Jul. PMID 6248420
  5. Ethylzingerone, a Novel Compound with Antifungal Activity. Rossignol T, et al. Antimicrob Agents Chemother, 2021 Mar 18. PMID 33468481, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphoribosylanthranilate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylanthranilate isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylanthranilate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylanthranilate isomerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphoribosylanthranilate isomerase activity RCA
inferred from Reviewed Computational Analysis
more info
  
Process Evidence Code Pubs
involved_in L-tryptophan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-tryptophan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-tryptophan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-tryptophan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-tryptophan biosynthetic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in aromatic amino acid biosynthetic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in chorismate metabolic process RCA
inferred from Reviewed Computational Analysis
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
  
Preferred Names
phosphoribosylanthranilate isomerase TRP1
NP_010290.3
  • Phosphoribosylanthranilate isomerase; catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA); enhances vegetative growth at low and high temperatures when used as an auxotrophic marker in strains such as W303

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    461842..462516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180315.3 → NP_010290.3  phosphoribosylanthranilate isomerase TRP1

    See identical proteins and their annotated locations for NP_010290.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRZ5, P00912, Q03448, Q12131, Q70DA4, Q70DA7, Q70DB2, Q7LHE0
    UniProtKB/TrEMBL
    A6ZXX3, B3LGQ1, B5VFR6, C7GXY3, C8Z4S7, G2WAB5, K4HWW7, K4HWY4, K4HWY8, K4HZS4, K4I8G4, K4I8J0, N1P607
    Conserved Domains (1) summary
    pfam00697
    Location:24 → 220
    PRAI; N-(5'phosphoribosyl)anthranilate (PRA) isomerase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00912.2

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