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PTC1 type 2C protein phosphatase PTC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851558, updated on 10-Oct-2019

Summary

Gene symbol
PTC1
Gene description
type 2C protein phosphatase PTC1
Primary source
SGD:S000002164
Locus tag
YDL006W
Gene type
protein coding
RNA name
type 2C protein phosphatase PTC1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CWH47; KCS2; TPD1

Genomic context

See PTC1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (439909..440754)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene proteasome regulatory particle base subunit RPT2 Neighboring gene Med2p Neighboring gene F1F0 ATP synthase subunit delta

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the PTC1 gene: The PTC1 gene is conserved in S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and rice.

Gene Ontology Provided by GO

Function Evidence Code Pubs
MAP kinase serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
cation binding IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium-dependent protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
inactivation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
inactivation of MAPK activity IGI
Inferred from Genetic Interaction
more info
PubMed 
inactivation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
inactivation of MAPKK activity IGI
Inferred from Genetic Interaction
more info
PubMed 
mitochondrion inheritance IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-threonine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
tRNA splicing, via endonucleolytic cleavage and ligation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
type 2C protein phosphatase PTC1
NP_010278.3
  • Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    439909..440754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180065.3NP_010278.3  TPA: type 2C protein phosphatase PTC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010278.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35182
    Conserved Domains (1) summary
    smart00332
    Location:12279
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
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