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GPD1 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851539, updated on 9-Jun-2019

Summary

Gene symbol
GPD1
Gene description
glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1
Primary source
SGD:S000002180
Locus tag
YDL022W
Gene type
protein coding
RNA name
glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DAR1; HOR1; OSG1; OSR5

Genomic context

See GPD1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (411825..413000)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative acid phosphatase DIA3 Neighboring gene hypothetical protein Neighboring gene tRNA Neighboring gene phosphoglycerate mutase family protein GPM2 Neighboring gene stress-regulated transcription factor RPN4

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the GPD1 gene: The GPD1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
 
glycerol-3-phosphate dehydrogenase [NAD+] activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerol-3-phosphate dehydrogenase [NAD+] activity IEA
Inferred from Electronic Annotation
more info
 
glycerol-3-phosphate dehydrogenase [NAD+] activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NADH oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADH oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycerol-3-phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
 
glycerol-3-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerol-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
intracellular accumulation of glycerol IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein import into peroxisome matrix IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
glycerol-3-phosphate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1
NP_010262.1
  • NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases Ypk1p and Ypk2p, dephosphorylation increases catalytic activity; forms a heterodimer with Pnc1p to facilitate its peroxisomal import

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    411825..413000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180081.1NP_010262.1  TPA: glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010262.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q00055
    Conserved Domains (1) summary
    TIGR03376
    Location:36383
    glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
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