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SIR2 NAD-dependent histone deacetylase SIR2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851520, updated on 5-Jun-2017
Gene symbol
SIR2
Gene description
NAD-dependent histone deacetylase SIR2
Primary source
SGD:S000002200
Locus tag
YDL042C
Gene type
protein coding
RNA name
NAD-dependent histone deacetylase SIR2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MAR1
See SIR2 in Map Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (376757..378445, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mtf2p Neighboring gene Prp11p Neighboring gene peptide alpha-N-acetyltransferase complex A subunit NAT1 Neighboring gene pheromone-regulated protein PRM7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity (H3-K14 specific) IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K9 specific) IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent histone deacetylase activity (H4-K16 specific) IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to nucleosome binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
chromatin assembly or disassembly IDA
Inferred from Direct Assay
more info
PubMed 
chromatin organization IGI
Inferred from Genetic Interaction
more info
PubMed 
chromatin silencing IEA
Inferred from Electronic Annotation
more info
 
chromatin silencing at rDNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin silencing at silent mating-type cassette IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin silencing at telomere IMP
Inferred from Mutant Phenotype
more info
PubMed 
chronological cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
covalent chromatin modification IEA
Inferred from Electronic Annotation
more info
 
histone H3 deacetylation IEA
Inferred from Electronic Annotation
more info
 
histone H3-K9 deacetylation IEA
Inferred from Electronic Annotation
more info
 
histone H3-K9 modification IEA
Inferred from Electronic Annotation
more info
 
histone H4 deacetylation IEA
Inferred from Electronic Annotation
more info
 
histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA amplification IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deacetylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
replicative cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere tethering at nuclear periphery IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RENT complex IDA
Inferred from Direct Assay
more info
PubMed 
chromatin silencing complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromosome, telomeric region IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear telomeric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
NAD-dependent histone deacetylase SIR2
NP_010242.1
  • Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    376757..378445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180101.1NP_010242.1  TPA: NAD-dependent histone deacetylase SIR2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010242.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06700
    Conserved Domains (2) summary
    cd01408
    Location:255517
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    pfam04574
    Location:104261
    DUF592; Protein of unknown function (DUF592)
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