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ITGA10 integrin subunit alpha 10 [ Homo sapiens (human) ]

Gene ID: 8515, updated on 11-Jun-2021

Summary

Official Symbol
ITGA10provided by HGNC
Official Full Name
integrin subunit alpha 10provided by HGNC
Primary source
HGNC:HGNC:6135
See related
Ensembl:ENSG00000143127 MIM:604042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRO827
Summary
Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Broad expression in lung (RPKM 2.4), heart (RPKM 1.3) and 22 other tissues See more
Orthologs
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Genomic context

See ITGA10 in Genome Data Viewer
Location:
1q21.1
Exon count:
29
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (145891208..145910050, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145525030..145543868)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 35 Neighboring gene uncharacterized LOC107985593 Neighboring gene peroxisomal biogenesis factor 11 beta Neighboring gene gonadotropin releasing hormone receptor 2 (pseudogene) Neighboring gene RNA binding motif protein 8A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables collagen binding TAS
Traceable Author Statement
more info
PubMed 
enables collagen binding involved in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extracellular matrix organization TAS
Traceable Author Statement
more info
 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of integrin alpha10-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin complex TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303040.2NP_001289969.1  integrin alpha-10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks three alternate exons in the 5' coding region and uses an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC243547, AF112345, AK304155, BM311010
    UniProtKB/Swiss-Prot
    O75578
    UniProtKB/TrEMBL
    B4E282
    Conserved Domains (3) summary
    smart00191
    Location:414468
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:35215
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:511919
    Integrin_alpha2; Integrin alpha
  2. NM_001303041.2NP_001289970.1  integrin alpha-10 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001289970.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks four alternate exons in the 5' coding region but maintains the reading frame compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AF112345, BC140831
    Consensus CDS
    CCDS76204.1
    UniProtKB/Swiss-Prot
    O75578
    Related
    ENSP00000439894.1, ENST00000539363.2
    Conserved Domains (3) summary
    smart00191
    Location:402456
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:23203
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:499907
    Integrin_alpha2; Integrin alpha
  3. NM_003637.5NP_003628.2  integrin alpha-10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003628.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC243547, AF074015, AF112345
    Consensus CDS
    CCDS72869.1
    UniProtKB/Swiss-Prot
    O75578
    Related
    ENSP00000358310.3, ENST00000369304.8
    Conserved Domains (3) summary
    smart00191
    Location:545599
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:166346
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:6421050
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    145891208..145910050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005277436.3XP_005277493.1  integrin alpha-10 isoform X5

    Conserved Domains (3) summary
    smart00191
    Location:483537
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:104284
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:580988
    Integrin_alpha2; Integrin alpha
  2. XM_017002626.1XP_016858115.1  integrin alpha-10 isoform X6

  3. XM_017002623.1XP_016858112.1  integrin alpha-10 isoform X2

  4. XM_017002625.1XP_016858114.1  integrin alpha-10 isoform X4

  5. XM_017002624.1XP_016858113.1  integrin alpha-10 isoform X3

  6. XM_017002622.1XP_016858111.1  integrin alpha-10 isoform X1

  7. XM_011510083.2XP_011508385.1  integrin alpha-10 isoform X7

    Conserved Domains (3) summary
    smart00191
    Location:380434
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:1181
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:477885
    Integrin_alpha2; Integrin alpha
  8. XM_017002628.1XP_016858117.1  integrin alpha-10 isoform X9

  9. XM_011510084.1XP_011508386.1  integrin alpha-10 isoform X10

    Conserved Domains (2) summary
    smart00191
    Location:3690
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:133541
    Integrin_alpha2; Integrin alpha
  10. XM_017002627.1XP_016858116.1  integrin alpha-10 isoform X8

RNA

  1. XR_001737501.1 RNA Sequence

  2. XR_001737504.1 RNA Sequence

  3. XR_001737503.1 RNA Sequence

  4. XR_001737502.1 RNA Sequence

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