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TSR1 small subunit rRNA maturation protein TSR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851499, updated on 3-May-2025
Official Symbol
TSR1
Official Full Name
small subunit rRNA maturation protein TSR1
Primary source
SGD:S000002218
Locus tag
YDL060W
See related
AllianceGenome:SGD:S000002218; FungiDB:YDL060W; VEuPathDB:YDL060W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ribonucleoprotein complex binding activity. Involved in endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm and nucleolus. Part of 90S preribosome. Used to study chronic lymphocytic leukemia. Orthologous to human TSR1 (TSR1 ribosome maturation factor). [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
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See TSR1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (341619..343985)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Syo1p Neighboring gene ribosomal 40S subunit protein S29B Neighboring gene Rad59p Neighboring gene Uso1p

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases. McCaughan UM, et al. Nat Commun, 2016 Jun 2. PMID 27250689, Free PMC Article
  2. Bms1p, a novel GTP-binding protein, and the related Tsr1p are required for distinct steps of 40S ribosome biogenesis in yeast. Gelperin D, et al. RNA, 2001 Sep. PMID 11565749, Free PMC Article
  3. Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Wu LF, et al. Nat Genet, 2002 Jul. PMID 12089522
  4. Good Vibrations: Structural Remodeling of Maturing Yeast Pre-40S Ribosomal Particles Followed by Cryo-Electron Microscopy. Shayan R, et al. Molecules, 2020 Mar 3. PMID 32138239, Free PMC Article
  5. An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7. Rai J, et al. RNA, 2021 Feb. PMID 33219089, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7.
    Title: An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7.
  2. Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases.
    Title: Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U3 snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
small subunit rRNA maturation protein TSR1
NP_010223.1
  • Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    341619..343985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180119.1 → NP_010223.1  TPA: small subunit rRNA maturation protein TSR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010223.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRT6, Q03128, Q07381
    UniProtKB/TrEMBL
    B3LGV8, C7GJP8, C8Z4K9, N1P5T5
    Conserved Domains (1) summary
    COG5177
    Location:4 → 788
    COG5177; Uncharacterized conserved protein [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07381.1

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