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SYO1 Syo1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851497, updated on 3-Jun-2026
Official Symbol
SYO1
Official Full Name
Syo1p
Primary source
SGD:S000002221
Locus tag
YDL063C
See related
AllianceGenome:SGD:S000002221; FungiDB:YDL063C; VEuPathDB:YDL063C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables unfolded protein binding activity. Involved in protein import into nucleus and ribosomal large subunit biogenesis. Located in cytoplasm and nucleus. Used to study Diamond-Blackfan anemia. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia. Orthologous to human HEATR3 (HEAT repeat containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See SYO1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (338272..340134, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pex19p Neighboring gene E2 SUMO-conjugating protein UBC9 Neighboring gene 40S ribosomal protein uS14 RPS29B Neighboring gene small subunit rRNA maturation protein TSR1

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Dynamics of ribosome scanning and recycling revealed by translation complex profiling. Archer SK, et al. Nature, 2016 Jul 28. PMID 27437580
  2. Synchronizing nuclear import of ribosomal proteins with ribosome assembly. Kressler D, et al. Science, 2012 Nov 2. PMID 23118189
  3. Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones. Pausch P, et al. Nat Commun, 2015 Jun 26. PMID 26112308, Free PMC Article
  4. The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes. Wade CH, et al. Yeast, 2006 Mar. PMID 16544271
  5. Translation initiation factor eIF4G1 modulates assembly of the polypeptide exit tunnel region in yeast ribosome biogenesis. Tseng YT, et al. J Cell Sci, 2022 Jun 15. PMID 35615984

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Syo1p
NP_010220.1
  • Transport adaptor or symportin; assembly chaperone that co-translationally associates with nascent Rpl5p, preventing aggregation; facilitates synchronized nuclear coimport of two 5S-rRNA binding proteins, Rpl5p and Rpl11p, mediated by import receptor Kap104p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    338272..340134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180122.1 → NP_010220.1  Syo1p

    See identical proteins and their annotated locations for NP_010220.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRT4, P89893, Q07395, Q7LGT0
    UniProtKB/TrEMBL
    A6ZXR3, B3LGW0, C7GJP6, C8Z4K6, N1PAA1
    Conserved Domains (1) summary
    cd13394
    Location:15 → 615
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07395.1

Gene LinkOut

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