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IDP1 isocitrate dehydrogenase (NADP(+)) IDP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851493, updated on 18-Sep-2024

Summary

Official Symbol
IDP1
Official Full Name
isocitrate dehydrogenase (NADP(+)) IDP1
Primary source
SGD:S000002224
Locus tag
YDL066W
See related
AllianceGenome:SGD:S000002224; FungiDB:YDL066W; VEuPathDB:YDL066W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables isocitrate dehydrogenase (NADP+) activity. Involved in glutamate biosynthetic process. Located in mitochondrial nucleoid. Used to study high grade glioma. Human ortholog(s) of this gene implicated in several diseases, including D-2-hydroxyglutaric aciduria 2; carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and lung cancer (multiple). Orthologous to several human genes including IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See IDP1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (334835..336121)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cbs1p Neighboring gene cytochrome c oxidase subunit VIIa Neighboring gene Pex19p Neighboring gene E2 SUMO-conjugating protein UBC9

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables isocitrate dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables isocitrate dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables isocitrate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
enables isocitrate dehydrogenase (NADP+) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in NADP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glutamate biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in glyoxylate cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in isocitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in isocitrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
isocitrate dehydrogenase (NADP(+)) IDP1
NP_010217.1
  • Mitochondrial NADP-specific isocitrate dehydrogenase; catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    334835..336121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180125.1NP_010217.1  TPA: isocitrate dehydrogenase (NADP(+)) IDP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010217.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRT1, P21954
    UniProtKB/TrEMBL
    A6ZXR0, B3LGW3, B5VFK1, C7GJP4, C8Z4K3, G2WC95, N1P7R0
    Conserved Domains (1) summary
    PRK08299
    Location:18424
    PRK08299; NADP-dependent isocitrate dehydrogenase