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BRE1 E3 ubiquitin-protein ligase BRE1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851485, updated on 25-Jan-2022

Summary

Gene symbol
BRE1
Gene description
E3 ubiquitin-protein ligase BRE1
Primary source
SGD:S000002232
Locus tag
YDL074C
See related
AllianceGenome:SGD:S000002232
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA replication origin binding activity and ubiquitin protein ligase activity. Involved in several processes, including mitotic DNA damage checkpoint signaling; nucleic acid metabolic process; and protein ubiquitination. Colocalizes with chromatin. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RNF20 (ring finger protein 20) and RNF40 (ring finger protein 40). [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See BRE1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (324047..326149, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L31A Neighboring gene ncRNA Neighboring gene Ahk1p Neighboring gene Yet3p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via homologous recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in histone H2B conserved C-terminal lysine ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone monoubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in histone monoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic DNA double-strand break formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G1 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-dependent DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in subtelomeric heterochromatin assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomere maintenance via recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase BRE1
NP_010209.1
  • E3 ubiquitin ligase; forms heterodimer with Rad6p to regulate K63 polyubiquitination in response to oxidative stress and to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control; interacts with RNA-binding protein Npl3p, linking histone ubiquitination to mRNA processing; Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    324047..326149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180133.1NP_010209.1  TPA: E3 ubiquitin-protein ligase BRE1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010209.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07457
    Conserved Domains (4) summary
    COG1196
    Location:314600
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16499
    Location:646687
    RING-HC_BRE1_like; RING finger, HC subclass, found in yeast Bre1 and its homologs from eukaryotes
    pfam08647
    Location:441535
    BRE1; BRE1 E3 ubiquitin ligase
    NF033930
    Location:147416
    pneumo_PspA; pneumococcal surface protein A
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