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RXT3 Rxt3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851483, updated on 3-May-2025
Official Symbol
RXT3
Official Full Name
Rxt3p
Primary source
SGD:S000002234
Locus tag
YDL076C
See related
AllianceGenome:SGD:S000002234; FungiDB:YDL076C; VEuPathDB:YDL076C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in negative regulation of transcription by RNA polymerase I. Located in nucleus. Part of Rpd3L complex. [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (320668..321552, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene malate dehydrogenase MDH3 Neighboring gene Vam6p Neighboring gene ribosomal 60S subunit protein L31A Neighboring gene ncRNA

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Disruption and functional analysis of six ORFs on chromosome IV: YDL053c, YDL072c, YDL073w, YDL076c, YDL077c and YDL080c. Blasco A, et al. Yeast, 2000 Nov. PMID 11054825
  2. Natural Diversity in Pentose Fermentation Is Explained by Variations in Histone Deacetylases. Tamari Z, et al. Cell Rep, 2016 Jan 26. PMID 26774473
  3. Determining protein complex connectivity using a probabilistic deletion network derived from quantitative proteomics. Sardiu ME, et al. PLoS One, 2009 Oct 6. PMID 19806189, Free PMC Article
  4. Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex. Patel AB, et al. Nat Commun, 2023 May 27. PMID 37244892, Free PMC Article
  5. Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Carrozza MJ, et al. Biochim Biophys Acta, 2005 Nov 10. PMID 16314178

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Rpd3L complex HDA PubMed 
part_of Rpd3L complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rpd3L-Expanded complex HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Rxt3p
NP_010207.1
  • Component of the Rpd3L histone deacetylase complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    320668..321552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180135.1 → NP_010207.1  TPA: Rxt3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010207.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRS3, Q07458
    UniProtKB/TrEMBL
    A6ZXQ2, B3LGX1, B5VFJ2, C7GJN6, C8Z4J4, N1P5R8
    Conserved Domains (1) summary
    pfam08642
    Location:140 → 252
    Rxt3; Histone deacetylation protein Rxt3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07458.1

Gene LinkOut

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