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VAM6 Vam6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851482, updated on 5-Oct-2021

Summary

Gene symbol
VAM6
Gene description
Vam6p
Primary source
SGD:S000002235
Locus tag
YDL077C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CVT4; VPL18; VPL22; VPS39
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Genomic context

See VAM6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (316971..320120, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative serine/threonine protein kinase MRK1 Neighboring gene malate dehydrogenase MDH3 Neighboring gene Rxt3p Neighboring gene ribosomal 60S subunit protein L31A

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endosomal vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in piecemeal microautophagy of the nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of TORC1 signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of SNARE complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in vacuole fusion, non-autophagic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vacuole organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle tethering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of HOPS complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole-mitochondrion membrane contact site IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Vam6p
NP_010206.1
  • Guanine nucleotide exchange factor for the GTPase Gtr1p; subunit of the HOPS endocytic tethering complex; vacuole membrane protein; functions as a Rab GTPase effector, interacting with both GTP- and GDP-bound conformations of Ypt7p; facilitates tethering and promotes membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; component of vacuole-mitochondrion contacts (vCLAMPs) important for lipid transfer between organelles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    316971..320120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180136.1NP_010206.1  TPA: Vam6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010206.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07468
    Conserved Domains (2) summary
    pfam10366
    Location:603715
    Vps39_1; Vacuolar sorting protein 39 domain 1
    pfam10367
    Location:9051016
    Vps39_2; Vacuolar sorting protein 39 domain 2
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