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LUC7 Luc7p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851471, updated on 6-Jul-2026
Official Symbol
LUC7
Official Full Name
Luc7p
Primary source
SGD:S000002245
Locus tag
YDL087C
See related
AllianceGenome:SGD:S000002245; FungiDB:YDL087C; VEuPathDB:YDL087C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
EPE1; EXM2
Summary
Enables mRNA binding activity. Involved in mRNA splice site recognition. Located in cytosol and nucleus. Part of U1 snRNP and U2-type prespliceosome. Orthologous to several human genes including LUC7L (LUC7 like). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See LUC7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (300214..300999, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Nur1p Neighboring gene FG-nucleoporin ASM4 Neighboring gene carboxymethylenebutenolidase Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Functional analysis of the zinc finger modules of the Saccharomyces cerevisiae splicing factor Luc7. Carrocci TJ, et al. RNA, 2024 Jul 16. PMID 38719745, Free PMC Article
  2. The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human. Puig O, et al. Nucleic Acids Res, 2007. PMID 17726058, Free PMC Article
  3. The FF domains of yeast U1 snRNP protein Prp40 mediate interactions with Luc7 and Snu71. Ester C, et al. BMC Biochem, 2008 Nov 11. PMID 19014439, Free PMC Article
  4. An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes. Kofoed M, et al. G3 (Bethesda), 2015 Jul 14. PMID 26175450, Free PMC Article
  5. Adaptive transcription-splicing resynchronization upon losing an essential splicing factor. Chang SL, et al. Nat Ecol Evol, 2018 Nov. PMID 30297747

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional analysis of the zinc finger modules of the Saccharomyces cerevisiae splicing factor Luc7.
    Title: Functional analysis of the zinc finger modules of the Saccharomyces cerevisiae splicing factor Luc7.
  2. Luc7-(31-246) identified as a minimal functional protein. N-terminal 18-amino acid segment of Luc7 plays an important role in U1 snRNP function.
    Title: Structure-function analysis and genetic interactions of the Luc7 subunit of the Saccharomyces cerevisiae U1 snRNP.
  3. The C-terminal 2 FF domains of Prp40 are dispensable; deletion of additional FF domains is lethal; The first FF domain of Prp40 binds to U1 protein Luc7 and domains 2 and 3 bind to Snu71, another known U1 protein.
    Title: The FF domains of yeast U1 snRNP protein Prp40 mediate interactions with Luc7 and Snu71.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA 5'-splice site recognition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splice site recognition IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splice site recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U1 snRNP IEA
Inferred from Electronic Annotation
more info
  
part_of U1 snRNP IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of U1 snRNP NAS
Non-traceable Author Statement
more info
 PubMed 
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type prespliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of commitment complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of spliceosomal complex NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
Luc7p
NP_010196.1
  • Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; relocalizes to the cytosol in response to hypoxia

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    300214..300999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180146.1 → NP_010196.1  Luc7p

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRR1, Q07508
    UniProtKB/TrEMBL
    B3LGY2
    Conserved Domains (1) summary
    COG5200
    Location:8 → 261
    LUC7; U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07508.1

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