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GET3 guanine nucleotide exchange factor GET3 [ Saccharomyces cerevisiae S288c ]

Gene ID: 851458, updated on 21-Mar-2017
Gene symbol
GET3
Gene description
guanine nucleotide exchange factor GET3
Primary source
SGD:S000002258
Locus tag
YDL100C
Gene type
protein coding
RNA name
guanine nucleotide exchange factor GET3
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ARR4
See GET3 in Map Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (282112..283176, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DNA-directed DNA polymerase delta POL3 Neighboring gene serine/threonine protein kinase DUN1 Neighboring gene Bug1p Neighboring gene U4/U6-U5 snRNP complex subunit SNU23

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
GET complex IPI
Inferred from Physical Interaction
more info
PubMed 
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
Names
guanine nucleotide exchange factor GET3
NP_010183.1
  • Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; functions as a chaperone under ATP-depleted oxidative stress conditions; subunit of GET complex, involved in ATP dependent Golgi to ER trafficking and insertion of tail-anchored (TA) proteins into ER membrane under non-stress conditions; binds as dimer to transmembrane domain (TMD) cargo, shielding TMDs from aqueous solvent; protein abundance increases under DNA replication stress

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    282112..283176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180159.1NP_010183.1  TPA: guanine nucleotide exchange factor GET3 [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_010183.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q12154
    Conserved Domains (2) summary
    COG0003
    Location:34354
    ArsA; Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism]
    TIGR00345
    Location:34334
    GET3_arsA_TRC40; transport-energizing ATPase, TRC40/GET3/ArsA family
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