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POL3 DNA-directed DNA polymerase delta POL3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851456, updated on 5-Jul-2025
Official Symbol
POL3
Official Full Name
DNA-directed DNA polymerase delta POL3
Primary source
SGD:S000002260
Locus tag
YDL102W
See related
AllianceGenome:SGD:S000002260; FungiDB:YDL102W; VEuPathDB:YDL102W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDC2; HPR6; TEX1
Summary
Enables 3'-5'-DNA exonuclease activity and DNA-directed DNA polymerase activity. Involved in DNA metabolic process. Located in replication fork. Used to study colorectal cancer and endometrial cancer. Human ortholog(s) of this gene implicated in immunodeficiency 120. Orthologous to human POLD1 (DNA polymerase delta 1, catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See POL3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (276872..280165)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative N(6)-L-threonylcarbamoyladenine synthase Neighboring gene UDP-N-acetylglucosamine diphosphorylase Neighboring gene serine/threonine protein kinase DUN1 Neighboring gene guanine nucleotide exchange factor GET3

Genomic Sequence:
NC_001136.10

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3'-5'-DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3'-5'-DNA exonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed DNA polymerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA replication proofreading IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA replication proofreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA replication, removal of RNA primer IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA-templated DNA replication maintenance of fidelity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in RNA-templated DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in base-excision repair, gap-filling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair via nonhomologous end joining IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of delta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of delta DNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of delta DNA polymerase complex TAS
Traceable Author Statement
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in replication fork IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
DNA-directed DNA polymerase delta POL3
NP_010181.2
  • Catalytic subunit of DNA polymerase delta; responsible for most of lagging strand DNA synthesis; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    276872..280165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180161.2NP_010181.2  TPA: DNA-directed DNA polymerase delta POL3

    See identical proteins and their annotated locations for NP_010181.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRP8, P15436
    UniProtKB/TrEMBL
    A6ZXM7, C8Z6K2
    Conserved Domains (1) summary
    PTZ00166
    Location:901095
    PTZ00166; DNA polymerase delta catalytic subunit; Provisional