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KIN28 TFIIH complex serine/threonine-protein kinase subunit KIN28 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851450, updated on 11-Jun-2025
Official Symbol
KIN28
Official Full Name
TFIIH complex serine/threonine-protein kinase subunit KIN28
Primary source
SGD:S000002266
Locus tag
YDL108W
See related
AllianceGenome:SGD:S000002266; FungiDB:YDL108W; VEuPathDB:YDL108W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA polymerase II CTD heptapeptide repeat kinase activity. Involved in RNA metabolic process and positive regulation of metabolic process. Located in cytosol and nucleus. Part of transcription factor TFIIK complex. Used to study brachydactyly type A2; breast cancer; essential hypertension; glucose metabolism disease (multiple); and primary congenital glaucoma. Orthologous to human CDK7 (cyclin dependent kinase 7). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
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See KIN28 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_001136.10 (267698..268699)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Tma17p Neighboring gene putative lipase Neighboring gene Mss2p Neighboring gene Pho2p

Genomic Sequence:
NC_001136.10

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription factor TFIIH holo complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor TFIIH holo complex IEA
Inferred from Electronic Annotation
more info
 
part_of transcription factor TFIIK complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription factor TFIIK complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor TFIIK complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
TFIIH complex serine/threonine-protein kinase subunit KIN28
NP_010175.1
  • Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly; phosphorylates the C-terminal domain (CTD) of RNAPII (Ser5 and Ser7); facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex; minor role in RNAPII transcription; role in RNAPI transcription; regulates Atg1p kinase complex assembly during nitrogen starvation induced autophagy; associates with cyclin Ccl1p; relocalizes to the cytosol in response to hypoxia; ortholog of human CDK7

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    267698..268699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180167.1NP_010175.1  TPA: TFIIH complex serine/threonine-protein kinase subunit KIN28 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010175.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRP2, P06242
    UniProtKB/TrEMBL
    A6ZXM1, B3LGZ9, C8Z6J6, G2WC54, N1P423
    Conserved Domains (1) summary
    cd07841
    Location:7302
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7