U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CYK3 Cyk3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851440, updated on 2-Nov-2024

Summary

Official Symbol
CYK3
Official Full Name
Cyk3p
Primary source
SGD:S000002275
Locus tag
YDL117W
See related
AllianceGenome:SGD:S000002275; FungiDB:YDL117W; VEuPathDB:YDL117W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme regulator activity. Involved in secondary cell septum biogenesis. Located in cellular bud neck contractile ring. Part of HICS complex. Human ortholog(s) of this gene implicated in myofibrillar myopathy 7. Orthologous to human KY (kyphoscoliosis peptidase). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CYK3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (248581..251238)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ferroxidase Neighboring gene Hem25p Neighboring gene Nup84p Neighboring gene Iwr1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme regulator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic division septum assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in secondary cell septum biogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in secondary cell septum biogenesis IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of HICS complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
 
located_in cellular bud neck contractile ring IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitotic actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
Cyk3p
NP_010166.1
  • SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    248581..251238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180176.1NP_010166.1  TPA: Cyk3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010166.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRN3, Q07533
    UniProtKB/TrEMBL
    G2WC44, N1P411
    Conserved Domains (2) summary
    COG5279
    Location:28882
    CYK3; Cytokinesis protein 3, contains TGc (transglutaminase/protease-like) domain [Cell cycle control, cell division, chromosome partitioning]
    cl17036
    Location:1365
    SH3; Src Homology 3 domain superfamily