U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CYK3 Cyk3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851440, updated on 4-Feb-2026
Official Symbol
CYK3
Official Full Name
Cyk3p
Primary source
SGD:S000002275
Locus tag
YDL117W
See related
AllianceGenome:SGD:S000002275; FungiDB:YDL117W; VEuPathDB:YDL117W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme regulator activity. Involved in secondary cell septum biogenesis. Located in cellular bud neck contractile ring. Part of HICS complex. Human ortholog(s) of this gene implicated in myofibrillar myopathy 7. Orthologous to human KY (kyphoscoliosis peptidase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See CYK3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (248581..251238)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ferroxidase Neighboring gene Hem25p Neighboring gene Nup84p Neighboring gene Iwr1p

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hof1 and Cyk3 interact directly at the time of cytokinesis by means of their respective SH3 and proline-rich domains
    Title: Role of the Hof1-Cyk3 interaction in cleavage-furrow ingression and primary-septum formation during yeast cytokinesis.
  2. Dephosphorylation of Inn1 by Cdc14 stabilizes the interaction between Inn1 and Cyk3.
    Title: Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation.
  3. Cyk3 is part of an actomyosin ring independent cytokinesis pathway, which acts as a rescue mechanism to recruit Inn1 to the bud neck.
    Title: Cyk3 acts in actomyosin ring independent cytokinesis by recruiting Inn1 to the yeast bud neck.
  4. Data show that the Inn1 C-terminal region is necessary for localization, and distinct PXXP motifs in this region mediate functionally important interactions with SH3 domains in the cytokinesis proteins Hof1 and Cyk3.
    Title: Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme regulator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic division septum assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in secondary cell septum biogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in secondary cell septum biogenesis IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of HICS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cellular bud neck contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
Preferred Names
Cyk3p
NP_010166.1
  • SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    248581..251238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180176.1 → NP_010166.1  Cyk3p

    See identical proteins and their annotated locations for NP_010166.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRN3, Q07533
    UniProtKB/TrEMBL
    G2WC44, N1P411
    Conserved Domains (2) summary
    COG5279
    Location:28 → 882
    CYK3; Cytokinesis protein 3, contains TGc (transglutaminase/protease-like) domain [Cell cycle control, cell division, chromosome partitioning]
    cl17036
    Location:13 → 65
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07533.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools