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aldo-keto reductase superfamily protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 851433, updated on 7-Jun-2026
Official Full Name
aldo-keto reductase superfamily protein
Primary source
SGD:S000002282
Locus tag
YDL124W
See related
AllianceGenome:SGD:S000002282; FungiDB:YDL124W; VEuPathDB:YDL124W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables aldose reductase (NADPH) activity; alpha-keto amide reductase activity; and alpha-ketoester reductase (NADPH) activity. Involved in cellular response to oxidative stress and ketone metabolic process. Located in cytoplasm; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (240259..241197)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene AAA family ATPase CDC48 Neighboring gene adenosine 5'-monophosphoramidase Neighboring gene Sna4p Neighboring gene ubiquitin-specific protease UBP1

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Using biocatalysis to integrate organic chemistry into a molecular biology laboratory course. Beers M, et al. Biochem Mol Biol Educ, 2012 Mar-Apr. PMID 22419594
  2. Purification and characterization of alpha-keto amide reductase from Saccharomyces cerevisiae. Ishihara K, et al. Biosci Biotechnol Biochem, 2004 Nov. PMID 15564669
  3. Enantiodivergent, biocatalytic routes to both taxol side chain antipodes. Feske BD, et al. J Org Chem, 2005 Nov 11. PMID 16268655
  4. Asymmetric synthesis of (S)-ethyl-4-chloro-3-hydroxy butanoate using a Saccharomyces cerevisiae reductase: enantioselectivity and enzyme-substrate docking studies. Jung J, et al. Biochim Biophys Acta, 2010 Sep. PMID 20601218
  5. Functional studies of aldo-keto reductases in Saccharomyces cerevisiae. Chang Q, et al. Biochim Biophys Acta, 2007 Mar. PMID 17140678, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YNL134C and YDL124W were also identified as candidate Yap2 target genes.
    Title: Candidate target genes for the Saccharomyces cerevisiae transcription factor, Yap2.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alcohol dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alcohol dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldose reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-keto amide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-ketoester reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ketone metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
Preferred Names
aldo-keto reductase superfamily protein
NP_010159.1
  • NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    240259..241197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180183.1 → NP_010159.1  aldo-keto reductase superfamily protein

    See identical proteins and their annotated locations for NP_010159.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRM6, Q07551
    UniProtKB/TrEMBL
    A6ZXK5, C8Z6H9, N1P5K1
    Conserved Domains (1) summary
    cd19120
    Location:13 → 291
    AKR_AKR3C2-3; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07551.1

Gene LinkOut

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