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HNT1 adenosine 5'-monophosphoramidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851432, updated on 18-Sep-2024

Summary

Official Symbol
HNT1
Official Full Name
adenosine 5'-monophosphoramidase
Primary source
SGD:S000002283
Locus tag
YDL125C
See related
AllianceGenome:SGD:S000002283; FungiDB:YDL125C; VEuPathDB:YDL125C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables adenosine 5'-monophosphoramidase activity. Involved in nucleotide metabolic process and response to zinc ion. Located in cytoplasm and nucleus. Used to study Gamstorp-Wohlfart syndrome. Human ortholog(s) of this gene implicated in Gamstorp-Wohlfart syndrome. Orthologous to human HINT1 (histidine triad nucleotide binding protein 1) and HINT2 (histidine triad nucleotide binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See HNT1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_001136.10 (239019..239606, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene cyclin PCL2 Neighboring gene AAA family ATPase CDC48 Neighboring gene aldo-keto reductase superfamily protein Neighboring gene Sna4p

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables adenosine 5'-monophosphoramidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenosine 5'-monophosphoramidase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in nucleotide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleotide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adenosine 5'-monophosphoramidase
NP_010158.1
  • Adenosine 5'-monophosphoramidase; interacts physically and genetically with CDK and TFIIK subunit Kin28p, and genetically with CAK1; member of histidine triad (HIT) superfamily of nucleotide-binding proteins; protein abundance increases in response to DNA replication stress; human homolog HINT1 can complement yeast hnt1 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    239019..239606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180184.1NP_010158.1  TPA: adenosine 5'-monophosphoramidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010158.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRM5, Q04344
    UniProtKB/TrEMBL
    A6ZXK4, B3LH15, C8Z6H8, N1P7K1
    Conserved Domains (1) summary
    cd01277
    Location:25122
    HINT_subgroup; HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. ...