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PPH21 phosphoprotein phosphatase 2A catalytic subunit PPH21 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851421, updated on 8-Feb-2025

Summary

Official Symbol
PPH21
Official Full Name
phosphoprotein phosphatase 2A catalytic subunit PPH21
Primary source
SGD:S000002292
Locus tag
YDL134C
See related
AllianceGenome:SGD:S000002292; FungiDB:YDL134C; VEuPathDB:YDL134C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine phosphatase activity. Involved in G1/S transition of mitotic cell cycle; positive regulation of autophagosome assembly; and regulation of translation. Acts upstream of or within regulation of TORC1 signaling. Located in cytoplasmic stress granule and nucleus. Part of protein phosphatase type 2A complex. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha) and PPP2CB (protein phosphatase 2 catalytic subunit beta). [provided by Alliance of Genome Resources, Feb 2025]
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Genomic context

See PPH21 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (219662..220771, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L35B Neighboring gene Rdi1p Neighboring gene ribosomal 60S subunit protein L41B Neighboring gene Srf1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables MAP kinase serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS140 phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of autophagosome assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of TORC1 signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translation IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
phosphoprotein phosphatase 2A catalytic subunit PPH21
NP_010147.1
  • Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph22p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    219662..220771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180193.1NP_010147.1  TPA: phosphoprotein phosphatase 2A catalytic subunit PPH21 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010147.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRL4, P23594
    UniProtKB/TrEMBL
    A6ZXJ3, B3LH26, C7GSS9, C8Z6G8, G2WC27, N1P5T1
    Conserved Domains (1) summary
    cd07415
    Location:70352
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain