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PPH21 phosphoprotein phosphatase 2A catalytic subunit PPH21 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851421, updated on 7-Jun-2026
Official Symbol
PPH21
Official Full Name
phosphoprotein phosphatase 2A catalytic subunit PPH21
Primary source
SGD:S000002292
Locus tag
YDL134C
See related
AllianceGenome:SGD:S000002292; FungiDB:YDL134C; VEuPathDB:YDL134C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine phosphatase activity. Involved in G1/S transition of mitotic cell cycle; positive regulation of autophagosome assembly; and regulation of translation. Acts upstream of or within regulation of TORC1 signaling. Located in cytoplasmic stress granule and nucleus. Part of protein phosphatase type 2A complex. Orthologous to several human genes including PPP2CA (protein phosphatase 2 catalytic subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See PPH21 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (219662..220771, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein uL29 RPL35B Neighboring gene Rdi1p Neighboring gene 60S ribosomal protein eL41 RPL41B Neighboring gene phospholipase D regulator

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers. Gentry MS, et al. Eukaryot Cell, 2005 Jun. PMID 15947195, Free PMC Article
  2. Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes. Sneddon AA, et al. EMBO J, 1990 Dec. PMID 2176150, Free PMC Article
  3. Role of protein phosphatase 2A in the control of glycogen metabolism in yeast. Clotet J, et al. Eur J Biochem, 1995 Apr 1. PMID 7744031
  4. Molecular genetic analysis of Rts1p, a B' regulatory subunit of Saccharomyces cerevisiae protein phosphatase 2A. Shu Y, et al. Mol Cell Biol, 1997 Jun. PMID 9154823, Free PMC Article
  5. Analysis of a 26,756 bp segment from the left arm of yeast chromosome IV. Wölfl S, et al. Yeast, 1996 Dec. PMID 8972577

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we conclude that Siw14 functions upstream of Pph21 and Pph22 as an inhibitor of the phosphorylation and localization of Gln3, and that Sit4 acts independently of Siw14
    Title: The protein phosphatase Siw14 controls caffeine-induced nuclear localization and phosphorylation of Gln3 via the type 2A protein phosphatases Pph21 and Pph22 in Saccharomyces cerevisiae.
  2. regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast
    Title: Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast.
  3. Pph21-Myc(13) (Ppp21 tagged at the C terminus with 13 copies of the Myc epitope) weakly associates with the DAL5 promoter in a Gat1-dependent manner, whereas a similar Pph22-Myc(13) association requires both Gln3 and Gat1.
    Title: Intranuclear function for protein phosphatase 2A: Pph21 and Pph22 are required for rapamycin-induced GATA factor binding to the DAL5 promoter in yeast.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in TOR signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagosome assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of TORC1 signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasmic stress granule HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein phosphatase type 2A complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
phosphoprotein phosphatase 2A catalytic subunit PPH21
NP_010147.1
  • Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph22p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    219662..220771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180193.1 → NP_010147.1  phosphoprotein phosphatase 2A catalytic subunit PPH21

    See identical proteins and their annotated locations for NP_010147.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRL4, P23594
    UniProtKB/TrEMBL
    A6ZXJ3, B3LH26, C7GSS9, C8Z6G8, G2WC27, N1P5T1
    Conserved Domains (1) summary
    cd07415
    Location:70 → 352
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23594.1

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