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PPH21 phosphoprotein phosphatase 2A catalytic subunit PPH21 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851421, updated on 5-Sep-2021

Summary

Gene symbol
PPH21
Gene description
phosphoprotein phosphatase 2A catalytic subunit PPH21
Primary source
SGD:S000002292
Locus tag
YDL134C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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Genomic context

See PPH21 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (219662..220771, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L35B Neighboring gene Rdi1p Neighboring gene ribosomal 60S subunit protein L41B Neighboring gene Srf1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the PPH21 gene: The PPH21 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphoprotein phosphatase 2A catalytic subunit PPH21
NP_010147.1
  • Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph22p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    219662..220771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180193.1NP_010147.1  TPA: phosphoprotein phosphatase 2A catalytic subunit PPH21 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010147.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P23594
    Conserved Domains (1) summary
    cd07415
    Location:70352
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
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