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CRD1 cardiolipin synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851413, updated on 8-Mar-2025

Summary

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Official Symbol
CRD1
Official Full Name
cardiolipin synthase
Primary source
SGD:S000002301
Locus tag
YDL142C
See related
AllianceGenome:SGD:S000002301; FungiDB:YDL142C; VEuPathDB:YDL142C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CLS1
Summary
Enables cardiolipin synthase (CMP-forming). Involved in several processes, including intracellular monoatomic ion homeostasis; mitochondrion organization; and protein targeting to membrane. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 57. Orthologous to human CRLS1 (cardiolipin synthase 1). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
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Genomic context

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See CRD1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (201719..202570, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene chaperonin-containing T-complex subunit CCT4 Neighboring gene biotin--[acetyl-CoA-carboxylase] ligase BPL1 Neighboring gene DNA-directed RNA polymerase II core subunit RPO21

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of cardiolipin synthase levels in Saccharomyces cerevisiae. Su X, et al. Yeast, 2006 Mar. PMID 16544270, Free PMC Article
  2. Cardiolipin is not required to maintain mitochondrial DNA stability or cell viability for Saccharomyces cerevisiae grown at elevated temperatures. Zhang M, et al. J Biol Chem, 2003 Sep 12. PMID 12840009
  3. Cardiolipin is a key determinant for mtDNA stability and segregation during mitochondrial stress. Luévano-Martínez LA, et al. Biochim Biophys Acta, 2015 Jun-Jul. PMID 25843549
  4. Cardiolipin biosynthesis and mitochondrial respiratory chain function are interdependent. Gohil VM, et al. J Biol Chem, 2004 Oct 8. PMID 15292198
  5. Functional Specificity of Cardiolipin Synthase Revealed by the Identification of a Cardiolipin Synthase CrCLS1 in Chlamydomonas reinhardtii. Hung CH, et al. Front Microbiol, 2015. PMID 26793177, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crd1, which is located in the mitochondrial inner membrane, condenses phosphatidylglycerol together with CDP-diacylglycerol to obtain de novo synthesized Cardiolipin molecules.
    Title: Genome-Wide Screens in Saccharomyces cerevisiae Highlight a Role for Cardiolipin in Biogenesis of Mitochondrial Outer Membrane Multispan Proteins.
  2. Results demonstrate the existence of a novel mitochondria-vacuole signaling pathway mediated by cardiolipin synthesis.
    Title: Cardiolipin mediates cross-talk between mitochondria and the vacuole.
  3. mitochondrial biosynthesis of phosphatidylethanolamine is essential for the viability of yeast mutants lacking cardiolipin
    Title: Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cardiolipin synthase (CMP-forming) IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cardiolipin synthase (CMP-forming) IDA
Inferred from Direct Assay
more info
 PubMed 
enables cardiolipin synthase (CMP-forming) IEA
Inferred from Electronic Annotation
more info
  
enables cardiolipin synthase (CMP-forming) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cardiolipin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular monoatomic ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cardiolipin synthase
NP_010139.1
  • Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function and for correct integration of membrane-multispanning proteins into the mitochondrial outer membrane; required to maintain tubular mitochondrial morphology and functions in mitochondrial fusion; also required for normal vacuolar ion homeostasis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    201719..202570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180202.1 → NP_010139.1  TPA: cardiolipin synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010139.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRK6, P82260, Q07560
    UniProtKB/TrEMBL
    A6ZXI5, B3LH33, B5VFC7, C8Z6G0, G2WC19, N1P7M8
    Conserved Domains (1) summary
    COG0558
    Location:66 → 231
    PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07560.1

Gene LinkOut

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