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STE7 mitogen-activated protein kinase kinase STE7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851396, updated on 30-Jul-2025
Official Symbol
STE7
Official Full Name
mitogen-activated protein kinase kinase STE7
Primary source
SGD:S000002318
Locus tag
YDL159W
See related
AllianceGenome:SGD:S000002318; FungiDB:YDL159W; VEuPathDB:YDL159W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables MAP kinase kinase activity. Involved in several processes, including MAPK cascade; invasive growth in response to glucose limitation; and pseudohyphal growth. Located in cytoplasm and mating projection tip. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; cardiofaciocutaneous syndrome 4; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1) and MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See STE7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (172481..174028)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DExD/H-box ATP-dependent RNA helicase DHH1 Neighboring gene uncharacterized protein Neighboring gene Dmo2p Neighboring gene Cmr1p

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning and characterization of a dual-specificity kinase gene in rice (Oryza sative). Du H, et al. Yi Chuan Xue Bao, 2005 Nov. PMID 16318282
  2. Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development. Köhler JR, et al. Proc Natl Acad Sci U S A, 1996 Nov 12. PMID 8917572, Free PMC Article
  3. cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates. Kosako H, et al. EMBO J, 1993 Feb. PMID 8440264, Free PMC Article
  4. Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase. Cairns BR, et al. Genes Dev, 1992 Jul. PMID 1628833
  5. In vivo selectively infective phage as a tool to detect protein interactions: evaluation of a novel vector system with yeast Ste7p-Fus3p interacting proteins. Hertveldt K, et al. Yeast, 2002 Apr. PMID 11921098

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ste7 ubiquitination determines mitogen-activated protein kinase specificity
    Title: Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.
  2. Data show that that two alternative MAPKKs, Pbs2 and Mkk2, can be forced to functionally replace the mating MAPKK Ste7, but only if the proper set of recruitment interactions are grafted onto their catalytic domains.
    Title: Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase.
  3. Data support the model that Fus3 activation in vivo requires binding to both Ste7 and the scaffold-Ste5, but that Kss1 activation is independent of Ste5.
    Title: Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell integrity MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in invasive growth in response to glucose limitation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pheromone response MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pheromone response MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in pheromone response MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pheromone response MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pheromone response MAPK cascade IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to pheromone IEA
Inferred from Electronic Annotation
more info
  
involved_in response to pheromone triggering conjugation with cellular fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction involved in filamentous growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell tip IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
mitogen-activated protein kinase kinase STE7
NP_010122.1
  • Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    172481..174028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180219.1 → NP_010122.1  TPA: mitogen-activated protein kinase kinase STE7

    See identical proteins and their annotated locations for NP_010122.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRJ2, P06784
    UniProtKB/TrEMBL
    A6ZXH1, B3LH45, G2WC05, N1P953
    Conserved Domains (1) summary
    cd06620
    Location:185 → 482
    PKc_Byr1_like; Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06784.1

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