GYP7 GTPase-activating protein GYP7 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GYP7
Official Full Name: GTPase-activating protein GYP7
Primary source: SGD:S000002393
Locus tag: YDL234C
See related: AllianceGenome:SGD:S000002393; FungiDB:YDL234C; VEuPathDB:YDL234C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables GTPase activator activity. Involved in regulation of vacuole fusion, non-autophagic and vesicle-mediated transport. Located in cytoplasm. Is active in late endosome. Orthologous to human TBC1D15 (TBC1 domain family member 15) and TBC1D17 (TBC1 domain family member 17). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See GYP7 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (34237..36477, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes.
Title: The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes.
Results show that the GTPase-activating protein Gyp7 inactivates the yeast vacuole Rab Ypt7 in vivo, with downstream assistance from an inhibitory casein kinase I, Yck3.
Title: Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of vacuole fusion, non-autophagic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in late endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: GTPase-activating protein GYP7

NP_010047.1

GTPase-activating protein for yeast Rab family members; members include Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; regulates Ypt7p activity on late endosomes; contains a PH-like domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

34237..36477 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180294.1 → NP_010047.1 GTPase-activating protein GYP7

See identical proteins and their annotated locations for NP_010047.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRC2, P48365

UniProtKB/TrEMBL

A6ZXA0, B3LHB0, C7GJQ3, C8Z6N7, N1P7L2

Conserved Domains (1) summary

COG5210
Location:134 → 738

COG5210; GTPase-activating protein [General function prediction only]