YPD1 Ypd1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YPD1
Official Full Name: Ypd1p
Primary source: SGD:S000002394
Locus tag: YDL235C
See related: AllianceGenome:SGD:S000002394; FungiDB:YDL235C; VEuPathDB:YDL235C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein histidine kinase binding activity and transferase activity, transferring phosphorus-containing groups. Involved in osmosensory signaling via phosphorelay pathway. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See YPD1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (33415..33918, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In silico free energy estimates, and sequence comparisons reveal distinctive electrostatic properties of the Ypd1/Ssk1-R2-W638A complex that may provide insight into the regulation of the Sln1 pathway as a function of dynamic osmolyte concentration.
Title: Insights revealed by the co-crystal structure of the Saccharomyces cerevisiae histidine phosphotransfer protein Ypd1 and the receiver domain of its downstream response regulator Ssk1.
partner binding interactions and phosphotransfer activity of the prototypical HPt protein Ypd1
Title: Role of the highly conserved G68 residue in the yeast phosphorelay protein Ypd1: implications for interactions between histidine phosphotransfer (HPt) and response regulator proteins.
network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae
Title: Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae.
Osmolytes negatively affect the stability of the SSK1-3YPD1 complex in a concentration-dependent manner and, as a consequence, the rate of phosphate hydrolysis increases.
Title: Effects of osmolytes on the SLN1-YPD1-SSK1 phosphorelay system from Saccharomyces cerevisiae.
Crystal structure of a complex between the phosphorelay protein YPD1 and the response regulator domain of SLN1 bound to a phosphoryl analog is reported.
Title: Crystal structure of a complex between the phosphorelay protein YPD1 and the response regulator domain of SLN1 bound to a phosphoryl analog.
analysis of the common docking site for response regulators on the yeast phosphorelay protein YPD1
Title: A common docking site for response regulators on the yeast phosphorelay protein YPD1.
Kinetic analysis of a eukaryotic "two-component" histidine-aspartic acid phosphotransfer system, enabling a comparison of the transfer rates and binding constants to the few bacterial systems that have been studied this way.
Title: Kinetic analysis of YPD1-dependent phosphotransfer reactions in the yeast osmoregulatory phosphorelay system.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables histidine phosphotransfer kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histidine phosphotransfer kinase activity	IEA Inferred from Electronic Annotation more info
enables protein histidine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein histidine kinase binding	IEA Inferred from Electronic Annotation more info
enables protein histidine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity, transferring phosphorus-containing groups	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in osmosensory signaling via phosphorelay pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in osmosensory signaling via phosphorelay pathway	IEA Inferred from Electronic Annotation more info
involved_in osmosensory signaling via phosphorelay pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorelay signal transduction system	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphorelay signal transduction system	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ypd1p

NP_010046.1

Osmotic stress-responsive phosphorelay intermediate sensor protein; phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus