PHO13 4-nitrophenylphosphatase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PHO13
Official Full Name: 4-nitrophenylphosphatase
Primary source: SGD:S000002395
Locus tag: YDL236W
See related: AllianceGenome:SGD:S000002395; FungiDB:YDL236W; VEuPathDB:YDL236W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables alkaline phosphatase activity; phosphoglycolate phosphatase activity; and phosphoprotein phosphatase activity. Involved in carbohydrate metabolic process. Located in cytoplasm and nucleus. Orthologous to human PGP (phosphoglycolate phosphatase) and PDXP (pyridoxal phosphatase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See PHO13 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (32296..33234)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphoglycolate phosphatase rescues central carbon metabolism from toxic secondary metabolites in humans and yeast.
Title: A Guardian Angel Phosphatase for Mainline Carbon Metabolism.
a conserved phosphatase (in yeast and mammals) destroys toxic glycolytic side products
Title: A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast.
Transcriptome sequencing analysis revealed that pho13Delta resulted in upregulation of the pentose phosphate (PP) pathway and NADPH-producing enzymes when cells were grown on glucose or xylose.
Title: Deletion of PHO13, encoding haloacid dehalogenase type IIA phosphatase, results in upregulation of the pentose phosphate pathway in Saccharomyces cerevisiae.
findings demonstrate that PHO13 deletion is a simple, but effective, approach for improving cellulosic bioethanol production by S. cerevisiae
Title: Deletion of the PHO13 gene in Saccharomyces cerevisiae improves ethanol production from lignocellulosic hydrolysate in the presence of acetic and formic acids, and furfural.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables alkaline phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkaline phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables alkaline phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoglycolate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoglycolate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoglycolate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in toxic metabolite repair	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: 4-nitrophenylphosphatase

NP_010045.1

EC 3.1.3.41

Conserved phosphatase acting as a metabolite repair enzyme; shows specific dephosphorylating activity on two side-products of central carbohydrate metabolism, 2-phosphoglycolate and 4-phosphoerythronate; alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; human ortholog PGP shows similar substrate specificity, deletion causes similar metabolite accumulation phenotypes, suggesting conserved role in eliminating glycolytic byproducts

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

32296..33234

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180296.1 → NP_010045.1 4-nitrophenylphosphatase

See identical proteins and their annotated locations for NP_010045.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRC0, P19881, Q07689

UniProtKB/TrEMBL

B3LHB2

Conserved Domains (1) summary

cd07510
Location:24 → 308

HAD_Pase_UmpH-like; UmpH/NagD family phosphatase, similar to human PGP phosphoglycolate phosphatase and Schizosaccharomyces pombe PHO2 p-nitrophenylphosphatase