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ADY3 Ady3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851359, updated on 23-Apr-2026
Official Symbol
ADY3
Official Full Name
Ady3p
Primary source
SGD:S000002398
Locus tag
YDL239C
See related
AllianceGenome:SGD:S000002398; FungiDB:YDL239C; VEuPathDB:YDL239C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable chromatin binding activity. Involved in ascospore wall assembly; ascospore-type prospore membrane formation; and mitochondrion inheritance. Located in peroxisome; prospore membrane leading edge; and spindle pole body. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See ADY3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (26403..28775, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene GTPase-activating protein LRG1 Neighboring gene guanine deaminase Neighboring gene Aim6p

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cytokinesis in yeast meiosis depends on the regulated removal of Ssp1p from the prospore membrane. Maier P, et al. EMBO J, 2007 Apr 4. PMID 17347652, Free PMC Article
  2. Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast. King GA, et al. Elife, 2019 Aug 9. PMID 31397671, Free PMC Article
  3. Alternative modes of organellar segregation during sporulation in Saccharomyces cerevisiae. Suda Y, et al. Eukaryot Cell, 2007 Nov. PMID 17905927, Free PMC Article
  4. The Smk1 MAPK and Its Activator, Ssp2, Are Required for Late Prospore Membrane Development in Sporulating Saccharomyces cerevisiae. Durant M, et al. J Fungi (Basel), 2021 Jan 14. PMID 33466572, Free PMC Article
  5. Ady3p links spindle pole body function to spore wall synthesis in Saccharomyces cerevisiae. Nickas ME, et al. Genetics, 2002 Apr. PMID 11973299, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ascospore wall assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ascospore-type prospore membrane formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion inheritance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrion inheritance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sporulation resulting in formation of a cellular spore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in condensed chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in prospore membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in prospore membrane IEA
Inferred from Electronic Annotation
more info
  
located_in prospore membrane leading edge HDA PubMed 
located_in prospore membrane leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole body IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole body IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
Ady3p
NP_010042.2
  • Protein required for spore wall formation; subunit of leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms ring-like structure at leading edge of prospore membrane during meiosis II; mediates assembly of LEP complex, formation of ring-like structure via interaction with spindle pole body components, and prospore membrane maturation; also detected in peroxisomes; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    26403..28775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180299.2 → NP_010042.2  Ady3p

    See identical proteins and their annotated locations for NP_010042.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRB7, Q07732
    UniProtKB/TrEMBL
    B3LHB5, C7GJQ8, N1P5X2
    Conserved Domains (3) summary
    COG1196
    Location:187 → 520
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK12704
    Location:482 → 603
    PRK12704; phosphodiesterase; Provisional
    pfam11778
    Location:655 → 789
    SID; Septation initiation
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07732.2

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