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AAD4 putative aryl-alcohol dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851354, updated on 18-Jan-2023

Summary

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Gene symbol
AAD4
Gene description
putative aryl-alcohol dehydrogenase
Primary source
SGD:S000002402
Locus tag
YDL243C
See related
AllianceGenome:SGD:S000002402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables aryl-alcohol dehydrogenase (NADP+) activity. Predicted to be involved in cellular aldehyde metabolic process. Orthologous to human AKR7A2 (aldo-keto reductase family 7 member A2) and AKR7A3 (aldo-keto reductase family 7 member A3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See AAD4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (17577..18566, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hexose transporter HXT15 Neighboring gene 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deciphering the Origin, Evolution, and Physiological Function of the Subtelomeric Aryl-Alcohol Dehydrogenase Gene Family in the Yeast Saccharomyces cerevisiae. Yang DD, et al. Appl Environ Microbiol, 2018 Jan 1. PMID 29079624, Free PMC Article
  2. Analysis of the seven-member AAD gene set demonstrates that genetic redundancy in yeast may be more apparent than real. Delneri D, et al. Genetics, 1999 Dec. PMID 10581269, Free PMC Article
  3. Disruption of seven hypothetical aryl alcohol dehydrogenase genes from Saccharomyces cerevisiae and construction of a multiple knock-out strain. Delneri D, et al. Yeast, 1999 Nov. PMID 10572264
  4. Mechanisms of patulin toxicity under conditions that inhibit yeast growth. Iwahashi Y, et al. J Agric Food Chem, 2006 Mar 8. PMID 16506856
  5. RNAi expression tuning, microfluidic screening, and genome recombineering for improved protein production in Saccharomyces cerevisiae. Wang G, et al. Proc Natl Acad Sci U S A, 2019 May 7. PMID 31000602, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables aryl-alcohol dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aryl-alcohol dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular aldehyde metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
putative aryl-alcohol dehydrogenase
NP_010038.1
  • Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    17577..18566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180303.1 → NP_010038.1  TPA: putative aryl-alcohol dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010038.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRB4, Q07747
    UniProtKB/TrEMBL
    A0A8H8UM61, N1P6T5
    Conserved Domains (1) summary
    cd19147
    Location:1 → 292
    AKR_AKR9A3_9B1-4; Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07747.1

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