THI13 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: THI13
Official Full Name: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
Primary source: SGD:S000002403
Locus tag: YDL244W
See related: AllianceGenome:SGD:S000002403; FungiDB:YDL244W; VEuPathDB:YDL244W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable metal ion binding activity and transferase activity. Involved in thiamine biosynthetic process. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See THI13 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (16204..17226)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

THI13 mutants had no significant effect on IL-10 production, though the IL-12 level was increased in the supernatants. These results suggest that THI13 is involved in the host effective immune response by regulating IL-10 and IL-12 production.
Title: Candida albicans THI13 disruption affects production of monocytic cytokines.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP	ISS Inferred from Sequence or Structural Similarity more info
enables 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP	RCA inferred from Reviewed Computational Analysis more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in thiamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in thiamine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thiamine biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in thiamine diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	RCA inferred from Reviewed Computational Analysis more info

General protein information

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Preferred Names: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase

NP_010037.1

Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

16204..17226

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180304.1 → NP_010037.1 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase

See identical proteins and their annotated locations for NP_010037.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRB3, Q07748

UniProtKB/TrEMBL

A6ZQB4, B3LHB9, C8ZGJ3

Conserved Domains (1) summary

cd13650
Location:5 → 255

PBP2_THI5; Substrate binding domain of ABC-type transporters for thiamin biosynthetic pathway intermediates; a member of the type 2 periplasmic binding fold superfamily