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INH1 ATPase inhibitor [ Saccharomyces cerevisiae S288C ]

Gene ID: 851347, updated on 3-May-2025
Official Symbol
INH1
Official Full Name
ATPase inhibitor
Primary source
SGD:S000002340
Locus tag
YDL181W
See related
AllianceGenome:SGD:S000002340; FungiDB:YDL181W; VEuPathDB:YDL181W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATPase inhibitor activity and enzyme inhibitor activity. Involved in negative regulation of ATP-dependent activity. Located in mitochondrion. [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
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See INH1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (135179..135436)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mrx19p Neighboring gene homocitrate synthase LYS20 Neighboring gene Ait1p Neighboring gene Pcl9p

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. How the N-terminal extremity of Saccharomyces cerevisiae IF1 interacts with ATP synthase: a kinetic approach. Andrianaivomananjaona T, et al. Biochim Biophys Acta, 2011 Feb. PMID 20951672
  2. A protein inhibitor of mitochondrial adenosine triphosphatase (F1) from Saccharomyces cerevisiae. Ebner E, et al. J Biol Chem, 1977 Jan 25. PMID 137903
  3. Binding of intrinsic ATPase inhibitor to mitochondrial ATPase--stoichiometry of binding of nucleotides, inhibitor, and enzyme. Hashimoto T, et al. J Biochem, 1981 Oct. PMID 6458600
  4. Amino acid sequence of an intrinsic inhibitor of mitochondrial ATPase from yeast. Matsubara H, et al. J Biochem, 1981 Oct. PMID 6458601
  5. Partial amino terminal sequence of the precursor of mitochondrial ATPase inhibitor protein synthesized with mRNA partially purified by gel permeation chromatography. Yoshida Y, et al. J Biochem, 1983 Jul. PMID 6619114

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATPase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATPase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of ATP-dependent activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ATPase inhibitor
NP_010100.1
  • Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has a calmodulin-binding motif and binds calmodulin in vitro; INH1 has a paralog, STF1, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    135179..135436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180241.1 → NP_010100.1  TPA: ATPase inhibitor [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010100.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRH1, P01097
    UniProtKB/TrEMBL
    A6ZXF0, B3LH65, C7GL27, C8Z6C3, G2WBY4, N1P7C4
    Conserved Domains (1) summary
    pfam04568
    Location:4 → 85
    IATP; Mitochondrial ATPase inhibitor, IATP
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01097.2

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