PPH22 phosphoprotein phosphatase 2A catalytic subunit PPH22 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PPH22
Official Full Name: phosphoprotein phosphatase 2A catalytic subunit PPH22
Primary source: SGD:S000002347
Locus tag: YDL188C
See related: AllianceGenome:SGD:S000002347; FungiDB:YDL188C; VEuPathDB:YDL188C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PPH2
Summary: Enables protein serine/threonine phosphatase activity. Involved in several processes, including mitotic cell cycle phase transition; negative regulation of ribonucleoprotein complex localization; and positive regulation of autophagosome assembly. Acts upstream of or within regulation of TORC1 signaling. Located in condensed chromosome, centromeric region and nuclear periphery. Is active in chromosome, telomeric region. Orthologous to several human genes including PPP2CA (protein phosphatase 2 catalytic subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See PPH22 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (123865..124998, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we conclude that Siw14 functions upstream of Pph21 and Pph22 as an inhibitor of the phosphorylation and localization of Gln3, and that Sit4 acts independently of Siw14
Title: The protein phosphatase Siw14 controls caffeine-induced nuclear localization and phosphorylation of Gln3 via the type 2A protein phosphatases Pph21 and Pph22 in Saccharomyces cerevisiae.
Pph21-Myc(13) (Ppp21 tagged at the C terminus with 13 copies of the Myc epitope) weakly associates with the DAL5 promoter in a Gat1-dependent manner, whereas a similar Pph22-Myc(13) association requires both Gln3 and Gat1.
Title: Intranuclear function for protein phosphatase 2A: Pph21 and Pph22 are required for rapamycin-induced GATA factor binding to the DAL5 promoter in yeast.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in G1/S transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TOR signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ribonucleoprotein complex localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of TORC1 signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromosome, telomeric region	IMP Inferred from Mutant Phenotype more info	PubMed
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 2A complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: phosphoprotein phosphatase 2A catalytic subunit PPH22

NP_010093.1

EC 3.1.3.16

Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph21p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; dephosphorylates Tel1p/Mec1p-phosphorylated Cdc13p to promote telomerase release from telomeres at G2/M; PPH22 has a paralog, PPH21, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

123865..124998 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180248.1 → NP_010093.1 phosphoprotein phosphatase 2A catalytic subunit PPH22

See identical proteins and their annotated locations for NP_010093.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRG5, P23595

UniProtKB/TrEMBL

A6ZXE4, B3LH71, C7GX43, C8Z6B5, G2WBX8, N1P775

Conserved Domains (1) summary

cd07415
Location:78 → 360

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain