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ARF1 Arf family GTPase ARF1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851335, updated on 7-Jun-2026
Official Symbol
ARF1
Official Full Name
Arf family GTPase ARF1
Primary source
SGD:S000002351
Locus tag
YDL192W
See related
AllianceGenome:SGD:S000002351; FungiDB:YDL192W; VEuPathDB:YDL192W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity. Involved in several processes, including Golgi vesicle transport; protein localization to Golgi membrane; and regulation of Golgi organization. Acts upstream of or within positive regulation of mitochondrial fission; positive regulation of mitochondrial fusion; and regulation of fatty acid metabolic process. Located in cytosol. Is active in Golgi apparatus and organelle membrane contact site. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to several human genes including ARF3 (ARF GTPase 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See ARF1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (116321..116866)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene glucose sensor Neighboring gene ditrans,polycis-polyprenyl diphosphate synthase Neighboring gene 60S ribosomal protein uL29 RPL35A Neighboring gene ubiquitin-ubiquitin ligase UFD2

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Analysis of Arf1 GTPase-Dependent Membrane Binding and Remodeling Using the Exomer Secretory Vesicle Cargo Adaptor. Paczkowski JE, et al. Methods Mol Biol, 2016. PMID 27632000, Free PMC Article
  2. Measurement of one and two bond N-C couplings in large proteins by TROSY-based J-modulation experiments. Liu Y, et al. J Magn Reson, 2009 Sep. PMID 19581113, Free PMC Article
  3. Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes. Spang A, et al. Proc Natl Acad Sci U S A, 1998 Sep 15. PMID 9736713, Free PMC Article
  4. A novel combinatorial approach of quantitative microscopy and in silico modeling deciphers Arf1-dependent Golgi size regulation. Iyer P, et al. Eur Phys J E Soft Matter, 2019 Dec 12. PMID 31834534
  5. Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis. Enkler L, et al. Nat Cell Biol, 2023 Aug. PMID 37400497, Free PMC Article

See all (215) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An interaction between beta'-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling.
    Title: An interaction between β'-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling.
  2. Structural basis for activation of Arf1 at the Golgi complex.
    Title: Structural basis for activation of Arf1 at the Golgi complex.
  3. The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus.
    Title: The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus.
  4. Arf1 directly recruits the Pik1-Frq1 PI4K complex to regulate the final stages of Golgi maturation.
    Title: Arf1 directly recruits the Pik1-Frq1 PI4K complex to regulate the final stages of Golgi maturation.
  5. Arf1 orchestrates Rab GTPase conversion at the trans-Golgi network.
    Title: Arf1 orchestrates Rab GTPase conversion at the trans-Golgi network.
  6. The Glo3 GAP crystal structure supports the molecular niche model for ArfGAPs in COPI coats.
    Title: The Glo3 GAP crystal structure supports the molecular niche model for ArfGAPs in COPI coats.
  7. Date show that ADP-ribosylation factor 1 (ARF1) deletion alters Vps74 distribution along Golgi stacks.
    Title: Vps74p controls Golgi size in an Arf1-dependent manner.
  8. Arf1 and the exomer cargo adaptor coordinate cargo sorting into subset of secretory vesicle carriers in the model organism Saccharomyces cerevisiae. Here, we detail the assays we used to explore the cooperative action of Arf1 and exomer to bind and remodel membranes.
    Title: Analysis of Arf1 GTPase-Dependent Membrane Binding and Remodeling Using the Exomer Secretory Vesicle Cargo Adaptor.
  9. The DCB/HUS domain amplifies the ability of Sec7 to activate Arf1 on the membrane surface by facilitating membrane insertion of the Arf1 amphipathic helix.
    Title: The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase.
  10. Arf1 is involved in mitochondrial homeostasis and dynamics, independent of its role in vesicular traffic.
    Title: The small GTPase Arf1 modulates mitochondrial morphology and function.
Submit: New GeneRIF Correction See all GeneRIFs (18)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Golgi to plasma membrane transport IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in Golgi vesicle transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mitochondrial fission IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mitochondrial fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of Golgi organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of fatty acid metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus EXP
Inferred from Experiment
more info
 PubMed 
located_in Golgi apparatus HDA PubMed 
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
is_active_in organelle membrane contact site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Arf family GTPase ARF1
NP_010089.1
  • ADP-ribosylation factor; GTPase of the Ras superfamily that regulates coated vesicle formation during intracellular trafficking within the Golgi; regulates mitochondrial fission, fusion and function, controlling the flow of fatty acids and metabolites from lipid droplets to peroxisomes and mitochondria; localizes to the Golgi apparatus and the active form to ER and lipid droplets; arf1 arf2 double null mutation is complemented by human ARF1, ARF4, ARF5, or ARF6

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    116321..116866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180252.1 → NP_010089.1  Arf family GTPase ARF1

    See identical proteins and their annotated locations for NP_010089.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRG1, P11076
    UniProtKB/TrEMBL
    A6ZXE0, B3LH74, C7GV54, C8Z6B1, G2WBX4, N1P6V2
    Conserved Domains (1) summary
    cl38936
    Location:5 → 179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11076.3

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