RTN2 Rtn2p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: RTN2
Official Full Name: Rtn2p
Primary source: SGD:S000002363
Locus tag: YDL204W
See related: AllianceGenome:SGD:S000002363; FungiDB:YDL204W; VEuPathDB:YDL204W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in ER-dependent peroxisome organization; endoplasmic reticulum organization; and response to endoplasmic reticulum stress. Located in cortical endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 12. Orthologous to several human genes including RTN2 (reticulon 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ER-dependent peroxisome organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum inheritance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum tubular network maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum tubular network organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum tubular network organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in cortical endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum tubular network	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed

NP_010077.1

Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Sec6p, Yip3p, and Sbh1p; less abundant than RTN1; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress