UGA4 Uga4p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: UGA4
Official Full Name: Uga4p
Primary source: SGD:S000002369
Locus tag: YDL210W
See related: AllianceGenome:SGD:S000002369; FungiDB:YDL210W; VEuPathDB:YDL210W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables gamma-aminobutyric acid:proton symporter activity and putrescine transmembrane transporter activity. Involved in gamma-aminobutyric acid transport; putrescine transport; and transmembrane transport. Located in fungal-type vacuole membrane. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The aim of this work was to study the mechanisms responsible for the differences in the profiles of UGA4 expression in growth conditions.
Title: GABA induction of the Saccharomyces cerevisiae UGA4 gene depends on the quality of the carbon source: role of the key transcription factors acting in this process.
The quality of the carbon source regulates UGA4 gene expression and the regulation is the result of two parallel pathways.
Title: New insights into the regulation of the Saccharomyces cerevisiae UGA4 gene: two parallel pathways participate in carbon-regulated transcription.
Extracellular amino acids regulate UGA4 expression and this effect seems to be mediated by the amino acid sensor complex SPS (SSY1, PTR3, SSY5).
Title: Expression of the UGA4 gene encoding the delta-aminolevulinic and gamma-aminobutyric acids permease in Saccharomyces cerevisiae is controlled by amino acid-sensing systems.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables gamma-aminobutyric acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-aminobutyric acid:proton symporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables putrescine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within IRES-dependent translational initiation of linear mRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gamma-aminobutyric acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in putrescine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in fungal-type vacuole membrane	HDA more info	PubMed
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info

NP_010071.1

GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane