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CDC13 telomere-binding protein CDC13 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851306, updated on 6-Feb-2018
Gene symbol
CDC13
Gene description
telomere-binding protein CDC13
Primary source
SGD:S000002379
Locus tag
YDL220C
Gene type
protein coding
RNA name
telomere-binding protein CDC13
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
EST4
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (62244..65018, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Hbt1p Neighboring gene Fmp45p Neighboring gene D-tyrosyl-tRNA(Tyr) deacylase Neighboring gene hypothetical protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
G-rich strand telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
single-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
single-stranded telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded telomeric DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomerase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
telomerase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
negative regulation of telomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of telomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
PubMed 
regulation of telomere maintenance via telomerase IGI
Inferred from Genetic Interaction
more info
PubMed 
ribonucleoprotein complex localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
 
telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere maintenance IEA
Inferred from Electronic Annotation
more info
 
telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere maintenance via telomerase IGI
Inferred from Genetic Interaction
more info
PubMed 
telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
CST complex IPI
Inferred from Physical Interaction
more info
PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
nuclear telomere cap complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Names
telomere-binding protein CDC13
NP_010061.1
  • Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles in regulation of telomerase, telomere end protection, conventional telomere replication; regulates telomere replication through recruitment of specific sub-complexes, essential function is telomere capping; forms homodimer via N-terminus; disruption of dimerization leads to short telomeres; autophagy and proteasome are involved in Cdc13p degradation; differentially phosphorylated through cell cycle

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    62244..65018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180280.1NP_010061.1  TPA: telomere-binding protein CDC13 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010061.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32797
    Conserved Domains (2) summary
    smart00976
    Location:510665
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    pfam16853
    Location:14241
    CDC13_N; Cell division control protein 13 N-terminus
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