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WHI4 Whi4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851302, updated on 11-May-2025
Official Symbol
WHI4
Official Full Name
Whi4p
Primary source
SGD:S000002383
Locus tag
YDL224C
See related
AllianceGenome:SGD:S000002383; FungiDB:YDL224C; VEuPathDB:YDL224C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable mRNA binding activity. Involved in mRNA destabilization and regulation of cell size. Located in cytoplasm. [provided by Alliance of Genome Resources, May 2025]
Orthologs
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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (54397..56346, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein GCS1 Neighboring gene septin SHS1 Neighboring gene Hbt1p Neighboring gene Fmp45p

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Effects of the yeast RNA-binding protein Whi3 on the half-life and abundance of CLN3 mRNA and other targets. Cai Y, et al. PLoS One, 2013. PMID 24386402, Free PMC Article
  2. Isolation and characterization of WHI3, a size-control gene of Saccharomyces cerevisiae. Nash RS, et al. Genetics, 2001 Apr. PMID 11290704, Free PMC Article
  3. Hypersensitive SSY1 mutations negatively influence transition to quiescence in yeast Saccharomyces cerevisiae. Marek A, et al. Yeast, 2021 Jan. PMID 33179371
  4. Conserved patterns of protein interaction in multiple species. Sharan R, et al. Proc Natl Acad Sci U S A, 2005 Feb 8. PMID 15687504, Free PMC Article
  5. The DNA damage response pathway contributes to the stability of chromosome III derivatives lacking efficient replicators. Theis JF, et al. PLoS Genet, 2010 Dec 2. PMID 21151954, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA destabilization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cell size IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Whi4p
NP_010057.1
  • Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    54397..56346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180284.1 → NP_010057.1  TPA: Whi4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010057.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRD1, Q07655
    UniProtKB/TrEMBL
    A6ZXB0, B5VF53, C7GSV4, C8Z6P5, N1P666
    Conserved Domains (1) summary
    cd12245
    Location:531 → 624
    RRM_scw1_like; RNA recognition motif (RRM) found in yeast cell wall integrity protein scw1 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07655.1

Gene LinkOut

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