Format

Send to:

Choose Destination

LIPF lipase F, gastric type [ Homo sapiens (human) ]

Gene ID: 8513, updated on 9-Jun-2020

Summary

Official Symbol
LIPFprovided by HGNC
Official Full Name
lipase F, gastric typeprovided by HGNC
Primary source
HGNC:HGNC:6622
See related
Ensembl:ENSG00000182333 MIM:601980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GL; HGL; HLAL
Summary
This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Expression
Restricted expression toward stomach (RPKM 9296.8) See more
Orthologs

Genomic context

See LIPF in Genome Data Viewer
Location:
10q23.31
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (88664442..88678815)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90424146..90438572)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929727 Neighboring gene renalase, FAD dependent amine oxidase Neighboring gene vomeronasal 1 receptor 55 pseudogene Neighboring gene lipase family member J Neighboring gene ribosomal protein L7 pseudogene 34 Neighboring gene N-ethylmaleimide-sensitive factor attachment protein, gamma pseudogene 1 Neighboring gene keratin 8 pseudogene 38 Neighboring gene lipase family member K

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138477, MGC142271

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding NAS
Non-traceable Author Statement
more info
PubMed 
malate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
triglyceride lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride lipase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
malate metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
triglyceride metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
gastric triacylglycerol lipase
Names
gastric lipase
lipase, gastric
NP_001185757.1
NP_001185758.1
NP_001185759.1
NP_004181.1
XP_011538613.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198828.2NP_001185757.1  gastric triacylglycerol lipase isoform 3 precursor

    See identical proteins and their annotated locations for NP_001185757.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AK301310, BM797485
    Consensus CDS
    CCDS55719.1
    UniProtKB/Swiss-Prot
    P07098
    Related
    ENSP00000477140.1, ENST00000608620.5
    Conserved Domains (2) summary
    PLN02872
    Location:4357
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:3582
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
  2. NM_001198829.2NP_001185758.1  gastric triacylglycerol lipase isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK301320, BM797485, X05997
    Consensus CDS
    CCDS55718.1
    UniProtKB/Swiss-Prot
    P07098
    Related
    ENSP00000377900.3, ENST00000394375.7
    Conserved Domains (3) summary
    PLN02872
    Location:14400
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:45107
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:88211
    Abhydrolase_5; Alpha/beta hydrolase family
  3. NM_001198830.2NP_001185759.1  gastric triacylglycerol lipase isoform 4 precursor

    See identical proteins and their annotated locations for NP_001185759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AL833751, BP341513
    Consensus CDS
    CCDS65896.1
    UniProtKB/Swiss-Prot
    P07098
    Related
    ENSP00000348101.3, ENST00000355843.2
    Conserved Domains (2) summary
    PLN02872
    Location:14367
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:4592
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
  4. NM_004190.4NP_004181.1  gastric triacylglycerol lipase isoform 2 precursor

    See identical proteins and their annotated locations for NP_004181.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    BM797485, BP341513, X05997
    Consensus CDS
    CCDS7389.1
    UniProtKB/Swiss-Prot
    P07098
    Related
    ENSP00000238983.4, ENST00000238983.8
    Conserved Domains (3) summary
    PLN02872
    Location:4390
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:3597
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:78201
    Abhydrolase_5; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    88664442..88678815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540311.1XP_011538613.1  gastric triacylglycerol lipase isoform X1

    See identical proteins and their annotated locations for XP_011538613.1

    UniProtKB/Swiss-Prot
    P07098
    Conserved Domains (3) summary
    PLN02872
    Location:4390
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:3597
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:78201
    Abhydrolase_5; Alpha/beta hydrolase family
Support Center