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ADE1 phosphoribosylaminoimidazolesuccinocarboxamide synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851272, updated on 12-Aug-2025
Official Symbol
ADE1
Official Full Name
phosphoribosylaminoimidazolesuccinocarboxamide synthase
Primary source
SGD:S000000070
Locus tag
YAR015W
See related
AllianceGenome:SGD:S000000070; FungiDB:YAR015W; VEuPathDB:YAR015W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in 'de novo' IMP biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See ADE1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (169375..170295)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ala Neighboring gene protein phosphatase regulator BUD14 Neighboring gene serine/threonine protein kinase KIN3 Neighboring gene serine/threonine protein kinase CDC15

Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Isolation and sequencing of a gene, C-ADE1, and its use for a host-vector system in Candida maltosa with two genetic markers. Kawai S, et al. Agric Biol Chem, 1991 Jan. PMID 1368674
  2. The Saccharomyces cerevisiae ADE1 gene: structure, overexpression and possible regulation by general amino acid control. Myasnikov AN, et al. Gene, 1991 Dec 20. PMID 1756975
  3. [Isolation and properties of phosphoribosyl-aminoimidazole-succinocarboxyamide-synthestase from Saccharomyces cerevisiae yeasts]. Ostanin KV, et al. Biokhimiia, 1989 Aug. PMID 2684279
  4. Enzymology of the pigmented adenine-requiring mutants of Saccharomyces and Schizosaccharomyces. Fisher CR. Biochem Biophys Res Commun, 1969 Feb 7. PMID 5767025
  5. [Cloning and physical mapping of the ADE1 gene of the yeast Saccharomyces cerevisiae]. Sasnauskas KV, et al. Genetika, 1986 Apr. PMID 3015720

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' IMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' IMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in purine ribonucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 
Preferred Names
phosphoribosylaminoimidazolesuccinocarboxamide synthase
NP_009409.1
  • N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase; required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    169375..170295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178216.1 → NP_009409.1  TPA: phosphoribosylaminoimidazolesuccinocarboxamide synthase

    See identical proteins and their annotated locations for NP_009409.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPM4, P27616
    UniProtKB/TrEMBL
    A0A0L8VVP7, A7A0H3, B3LUT3, B5VDM5, C7GUF6, C8Z3I5, G2W8N6, N1P7M3
    Conserved Domains (1) summary
    PRK13961
    Location:1 → 305
    PRK13961; phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27616.2

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