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EFB1 translation elongation factor 1 subunit beta [ Saccharomyces cerevisiae S288C ]

Gene ID: 851260, updated on 6-Jul-2026
Official Symbol
EFB1
Official Full Name
translation elongation factor 1 subunit beta
Primary source
SGD:S000000003
Locus tag
YAL003W
See related
AllianceGenome:SGD:S000000003; FungiDB:YAL003W; VEuPathDB:YAL003W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TEF5
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of actin filament bundle assembly; regulation of translational termination; and translation. Part of eukaryotic translation elongation factor 1 complex. Orthologous to several human genes including EEF1B2 (eukaryotic translation elongation factor 1 beta 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See EFB1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_001133.9 (142174..143160)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene tRNA-Pro Neighboring gene Hsp70 family ATPase SSA1 Neighboring gene ncRNA Neighboring gene CORVET complex membrane-binding subunit VPS8 Neighboring gene transcription factor TFIIIC subunit TFC3

Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning and characterization of the elongation factor EF-1 beta homologue of Saccharomyces cerevisiae. EF-1 beta is essential for growth. Hiraga K, et al. FEBS Lett, 1993 Jan 25. PMID 8420802
  2. Mutation of a conserved CDK site converts a metazoan Elongation Factor 1Bbeta subunit into a replacement for yeast eEF1Balpha. Pomerening JR, et al. Mol Genet Genomics, 2003 Sep. PMID 12898219
  3. Mutations in a GTP-binding motif of eukaryotic elongation factor 1A reduce both translational fidelity and the requirement for nucleotide exchange. Carr-Schmid A, et al. J Biol Chem, 1999 Oct 15. PMID 10514524
  4. Mutational analysis reveals potential phosphorylation sites in eukaryotic elongation factor 1A that are important for its activity. Mateyak MK, et al. FEBS Lett, 2021 Sep. PMID 34293820, Free PMC Article
  5. Increased expression of Saccharomyces cerevisiae translation elongation factor 1 alpha bypasses the lethality of a TEF5 null allele encoding elongation factor 1 beta. Kinzy TG, et al. Genetics, 1995 Oct. PMID 8647386, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. eEF1Bgamma co-immunoprecipitates with an essential component of ER-Golgi transport vesicles. Taken together, these results support a broader protein metabolism role for eEF1Bgamma.
    Title: The eukaryotic translation elongation Factor 1Bgamma has a non-guanine nucleotide exchange factor role in protein metabolism.
  2. The data obtained demonstrate involvement of the translation elongation factor eEF1B in modulating the functions of translation termination factors and suggest its possible role in GDP for GTP exchange on eRF3.
    Title: Elongation factor eEF1B modulates functions of the release factors eRF1 and eRF3 and the efficiency of translation termination in yeast.
  3. Coordination of eukaryotic translation elongation factor 1A (eEF1A) function in actin organization and translation elongation by the guanine nucleotide exchange factor eEF1Balpha.
    Title: Coordination of eukaryotic translation elongation factor 1A (eEF1A) function in actin organization and translation elongation by the guanine nucleotide exchange factor eEF1Balpha.
  4. Deletion of the two nonessential genes encoding eEF1Bgamma (TEF3 & TEF4) has no dramatic effects on total protein synthesis or translational fidelity. Instead, loss of each gene gives resistance to oxidative stress.
    Title: The translation elongation factor eEF1B plays a role in the oxidative stress response pathway.
  5. Mg2+ has a role in nucleotide exchange by eEF1B alpha and there is a catalytic function of Lys-205 in displacing Mg2+ from its binding site
    Title: Mg2+ and a key lysine modulate exchange activity of eukaryotic translation elongation factor 1B alpha.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maintenance of translational fidelity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of actin filament bundle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translational termination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation elongation factor 1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation elongation factor 1 complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of eukaryotic translation elongation factor 1 complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
translation elongation factor 1 subunit beta
NP_009398.1
  • Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site; human homolog EEF1B2 can complement yeast efb1 mutants

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    142174..143160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178150.1 → NP_009398.1  translation elongation factor 1 subunit beta

    See identical proteins and their annotated locations for NP_009398.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPL3, P32471
    UniProtKB/TrEMBL
    B3LUU2
    Conserved Domains (2) summary
    pfam00736
    Location:123 → 206
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    cl02776
    Location:12 → 57
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32471.4

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