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GCV3 glycine decarboxylase subunit H [ Saccharomyces cerevisiae S288C ]

Gene ID: 851254, updated on 3-Nov-2024

Summary

Official Symbol
GCV3
Official Full Name
glycine decarboxylase subunit H
Primary source
SGD:S000000042
Locus tag
YAL044C
See related
AllianceGenome:SGD:S000000042; FungiDB:YAL044C; VEuPathDB:YAL044C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables lipoic acid binding activity. Involved in glycine catabolic process; one-carbon metabolic process; and protein lipoylation. Located in mitochondrion. Part of glycine cleavage complex. Used to study glycine encephalopathy. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome. Orthologous to human GCSH (glycine cleavage system protein H). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See GCV3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (57950..58462, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Bol3p Neighboring gene Bol1p Neighboring gene RNA-processing protein PTA1 Neighboring gene Erv46p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lipoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in glycine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycine decarboxylation via glycine cleavage system IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycine decarboxylation via glycine cleavage system IEA
Inferred from Electronic Annotation
more info
 
involved_in one-carbon metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein lipoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of glycine cleavage complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of glycine cleavage complex IEA
Inferred from Electronic Annotation
more info
 
part_of glycine cleavage complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glycine decarboxylase subunit H
NP_009355.3
  • H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    57950..58462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178189.1NP_009355.3  TPA: glycine decarboxylase subunit H [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009355.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPH2, P39726
    UniProtKB/TrEMBL
    A7A0C2, B3LUY0, C7GPJ3, C8Z3E4, G2W8I6, N1P917
    Conserved Domains (1) summary
    TIGR00527
    Location:40169
    gcvH; glycine cleavage system H protein