U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BOL3 Bol3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851251, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
BOL3
Official Full Name
Bol3p
Primary source
SGD:S000000044
Locus tag
YAL046C
See related
AllianceGenome:SGD:S000000044; FungiDB:YAL046C; VEuPathDB:YAL046C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AIM1
Summary
Involved in protein maturation by [4Fe-4S] cluster transfer. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 2. Orthologous to human BOLA3 (bolA family member 3). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See BOL3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (57029..57385, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene ERMES complex Ca(2+)-binding regulatory GTPase GEM1 Neighboring gene gamma-tubulin complex subunit SPC72 Neighboring gene Bol1p Neighboring gene glycine decarboxylase subunit H

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins. Uzarska MA, et al. Elife, 2016 Aug 17. PMID 27532772, Free PMC Article
  2. Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients. Melber A, et al. Elife, 2016 Aug 17. PMID 27532773, Free PMC Article
  3. A Comprehensive Membrane Interactome Mapping of Sho1p Reveals Fps1p as a Novel Key Player in the Regulation of the HOG Pathway in S. cerevisiae. Lam MH, et al. J Mol Biol, 2015 Jun 5. PMID 25644660, Free PMC Article
  4. Genetic basis for Saccharomyces cerevisiae biofilm in liquid medium. Scherz K, et al. G3 (Bethesda), 2014 Jul 9. PMID 25009170, Free PMC Article
  5. The nucleotide sequence of chromosome I from Saccharomyces cerevisiae. Bussey H, et al. Proc Natl Acad Sci U S A, 1995 Apr 25. PMID 7731988, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein maturation by [4Fe-4S] cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation by [4Fe-4S] cluster transfer IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein maturation by [4Fe-4S] cluster transfer IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein maturation by [4Fe-4S] cluster transfer IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Bol3p
NP_009353.1
  • Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress by acting along with Nfu1p at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to mitochondrial client proteins like lipoate synthase and succinate dehydrogenase; sequence similarity to human BOLA family member, BOLA3, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS2)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    57029..57385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178191.1 → NP_009353.1  TPA: Bol3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009353.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPH0, P39724
    UniProtKB/TrEMBL
    A7A0C0, B3LUY2, C7GPJ1, C8Z3G6, G2W8I4, N1P7G9
    Conserved Domains (1) summary
    COG0271
    Location:33 → 110
    BolA; Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39724.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools