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ACS1 acetate--CoA ligase 1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851245, updated on 9-Sep-2018

Summary

Gene symbol
ACS1
Gene description
acetate--CoA ligase 1
Primary source
SGD:S000000050
Locus tag
YAL054C
Gene type
protein coding
RNA name
acetate--CoA ligase 1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FUN44

Genomic context

See ACS1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (42881..45022, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Gpb2p Neighboring gene ubiquitin-protein transferase activating protein PEX22 Neighboring gene flavin adenine dinucleotide transporter FLC2 Neighboring gene oleate-activated transcription factor OAF1

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
AMP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
acetate-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
acetate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
acid-ammonia (or amide) ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acetate fermentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acetyl-CoA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acetyl-CoA biosynthetic process from acetate IEA
Inferred from Electronic Annotation
more info
 
histone acetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane ISM
Inferred from Sequence Model
more info
PubMed 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acetate--CoA ligase 1
NP_009347.1
  • Acetyl-coA synthetase isoform; along with Acs2p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    42881..45022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178197.1NP_009347.1  TPA: acetate--CoA ligase 1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009347.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01574
    Conserved Domains (2) summary
    cd05966
    Location:80700
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
    TIGR02188
    Location:70710
    Ac_CoA_lig_AcsA; acetate--CoA ligase
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