ACS1 acetate--CoA ligase 1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ACS1
Official Full Name: acetate--CoA ligase 1
Primary source: SGD:S000000050
Locus tag: YAL054C
See related: AllianceGenome:SGD:S000000050; FungiDB:YAL054C; VEuPathDB:YAL054C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FUN44
Summary: Enables acetate-CoA ligase activity and acid-ammonia (or amide) ligase activity. Involved in acetate fermentation and acetyl-CoA biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to several human genes including ACSS1 (acyl-CoA synthetase short chain family member 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

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See ACS1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_001133.9 (42881..45022, complement)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis.
Title: FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis.
Acs1p is shown here to supply the acetyl-CoA for histone acetylation by histone acetyltransferases(HATs). In glycerol with ethanol, Acs1p is an alternate acetyl-CoA source for HATs
Title: Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables AMP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetate-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables acid-ammonia (or amide) ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetate fermentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acetyl-CoA biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetyl-CoA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within acetyl-CoA biosynthetic process from acetate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within small molecule metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acetate--CoA ligase 1

NP_009347.1

EC 6.2.1.1

Acetyl-coA synthetase isoform; along with Acs2p, acetyl-CoA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions; metabolites mediate the formation of filament assemblies in meiotic cells, storing Acs1p in an inactive state and promoting efficient return to growth after starvation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

42881..45022 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178197.1 → NP_009347.1 TPA: acetate--CoA ligase 1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009347.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPG4, Q01574, Q66RJ0

UniProtKB/TrEMBL

A7A0B4

Conserved Domains (1) summary

cd05966
Location:74 → 700

ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)