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PEX22 ubiquitin-protein transferase activating protein PEX22 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851244, updated on 9-Dec-2024

Summary

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Official Symbol
PEX22
Official Full Name
ubiquitin-protein transferase activating protein PEX22
Primary source
SGD:S000000051
Locus tag
YAL055W
See related
AllianceGenome:SGD:S000000051; FungiDB:YAL055W; VEuPathDB:YAL055W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YAF5
Summary
Enables ubiquitin-protein transferase activator activity. Involved in positive regulation of protein autoubiquitination and protein import into peroxisome matrix, receptor recycling. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PEX22 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (42177..42719)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene calnexin Neighboring gene Gpb2p Neighboring gene acetate--CoA ligase 1 Neighboring gene flavin adenine dinucleotide transporter FLC2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane. Koller A, et al. J Cell Biol, 1999 Jul 12. PMID 10402463, Free PMC Article
  2. Mutation in the peroxin-coding gene PEX22 contributing to high malate production in Saccharomyces cerevisiae. Negoro H, et al. J Biosci Bioeng, 2018 Feb. PMID 28919252
  3. A disulphide bond in the E2 enzyme Pex4p modulates ubiquitin-conjugating activity. Williams C, et al. Sci Rep, 2013. PMID 23896733, Free PMC Article
  4. Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling. Platta HW, et al. J Cell Biol, 2007 Apr 23. PMID 17452527, Free PMC Article
  5. The N-domain of Pex22p can functionally replace the Pex3p N-domain in targeting and peroxisome formation. Halbach A, et al. J Biol Chem, 2009 Feb 6. PMID 19017643

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mutation, causing Pex22p dysfunction, was sufficient to confer increased malate productivity and dimethyl succinate sensitivity to yeast cells
    Title: Mutation in the peroxin-coding gene PEX22 contributing to high malate production in Saccharomyces cerevisiae.
  2. The cytosolic domain of Pex22p stimulates the Pex4p-dependent ubiquitination of the PTS1-receptor (Pex5).
    Title: The cytosolic domain of Pex22p stimulates the Pex4p-dependent ubiquitination of the PTS1-receptor.
  3. The Pex4p:Pex22p assembly, and not Pex4p alone, functions as the E2 enzyme required for Pex5p ubiquitination. This is a novel mechanism of E2 enzyme regulation.
    Title: Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex.
  4. The N-domain of Pex22p can functionally replace the Pex3p N-domain in targeting and peroxisome formation.
    Title: The N-domain of Pex22p can functionally replace the Pex3p N-domain in targeting and peroxisome formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ubiquitin-protein transferase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in peroxisome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into peroxisome matrix, receptor recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin-protein transferase activating protein PEX22
NP_009346.1
  • Putative peroxisomal membrane protein; required for import of peroxisomal proteins; functionally complements a Pichia pastoris pex22 mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    42177..42719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178198.1 → NP_009346.1  TPA: ubiquitin-protein transferase activating protein PEX22 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009346.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPG3, P39718
    UniProtKB/TrEMBL
    G2W8H7
    Conserved Domains (1) summary
    pfam12827
    Location:51 → 167
    Peroxin-22; Peroxisomal biogenesis protein family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39718.1

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