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ERP2 Erp2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851226, updated on 23-Apr-2026
Official Symbol
ERP2
Official Full Name
Erp2p
Primary source
SGD:S000000005
Locus tag
YAL007C
See related
AllianceGenome:SGD:S000000005; FungiDB:YAL007C; VEuPathDB:YAL007C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein retention in ER lumen. Located in COPII-coated ER to Golgi transport vesicle. Orthologous to several human genes including TMED1 (transmembrane p24 trafficking protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See ERP2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (137698..138345, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Nem1-Spo7 phosphatase regulatory subunit SPO7 Neighboring gene Fun14p Neighboring gene tRNA-Pro Neighboring gene Hsp70 family ATPase SSA1

Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex. Marzioch M, et al. Mol Biol Cell, 1999 Jun. PMID 10359606, Free PMC Article
  2. The yeast p24 complex is required for the formation of COPI retrograde transport vesicles from the Golgi apparatus. Aguilera-Romero A, et al. J Cell Biol, 2008 Feb 25. PMID 18283113, Free PMC Article
  3. The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae. Springer S, et al. Proc Natl Acad Sci U S A, 2000 Apr 11. PMID 10737764, Free PMC Article
  4. A class of membrane proteins shaping the tubular endoplasmic reticulum. Voeltz GK, et al. Cell, 2006 Feb 10. PMID 16469703
  5. Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum. Li S, et al. Mol Biol Cell, 2010 Aug 1. PMID 20519439, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. genetic and physical interactions of p24alpha (Erp1, -5, and -6) and gamma (Erp2, -3, and -4). Deletion of the major p24alpha (Erp1) partially inhibited p24 activity as reported previously.
    Title: Isoform-selective oligomer formation of Saccharomyces cerevisiae p24 family proteins.
  2. Erp2p is required for the ER-Golgi cycling of ricin A chain prior to retrotranslocation from the yeast ER
    Title: Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum.
  3. Erp2p is required for the ER-Golgi cycling of ricin A chain expressed in the yeast ER lumen, prior to its dislocation and cytosolic entry
    Title: Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein retention in ER lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein retention in ER lumen IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle budding from membrane NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in COPII-coated ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi-associated vesicle NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Erp2p
NP_009395.1
  • Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP2 has a paralog, ERP4, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    137698..138345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178152.1 → NP_009395.1  Erp2p

    See identical proteins and their annotated locations for NP_009395.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPL1, P39704
    UniProtKB/TrEMBL
    A7A0G2, B3LUU4, B5VDL6, C7GPM7, C8Z3M3, G2W8M5, N1P8X3
    Conserved Domains (1) summary
    pfam01105
    Location:34 → 183
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39704.1

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