CYS3 cystathionine gamma-lyase CYS3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CYS3
Official Full Name: cystathionine gamma-lyase CYS3
Primary source: SGD:S000000010
Locus tag: YAL012W
See related: AllianceGenome:SGD:S000000010; FungiDB:YAL012W; VEuPathDB:YAL012W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CYI1; FUN35; STR1
Summary: Enables cystathionine gamma-lyase activity and cysteine-S-conjugate beta-lyase activity. Involved in cysteine biosynthetic process via cystathionine; positive regulation of hydrogen sulfide biosynthetic process; and transsulfuration. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The glutamate residue at position 333 is a determinant of specificity in cystathione gamma lyase.
Title: A role for glutamate-333 of Saccharomyces cerevisiae cystathionine γ-lyase as a determinant of specificity.
dual transcriptional regulation of CYS3 by factors that interact with the CDE1 motif and the CCG/CGC motif cis-elements
Title: Transcriptional regulation of Saccharomyces cerevisiae CYS3 encoding cystathionine gamma-lyase.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cystathionine gamma-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cystathionine gamma-lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables cystathionine gamma-lyase activity	IEA Inferred from Electronic Annotation more info
enables cystathionine gamma-lyase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-S-conjugate beta-lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-cysteine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-cysteine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-cysteine biosynthetic process via L-cystathionine	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-cysteine biosynthetic process via L-cystathionine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hydrogen sulfide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in transsulfuration	IBA Inferred from Biological aspect of Ancestor more info
involved_in transsulfuration	IEA Inferred from Electronic Annotation more info
involved_in transsulfuration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed

NP_009390.1

Cystathionine gamma-lyase; catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress