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CCR4 CCR4-NOT core exoribonuclease subunit CCR4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851212, updated on 5-Aug-2018

Summary

Gene symbol
CCR4
Gene description
CCR4-NOT core exoribonuclease subunit CCR4
Primary source
SGD:S000000019
Locus tag
YAL021C
Gene type
protein coding
RNA name
CCR4-NOT core exoribonuclease subunit CCR4
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FUN27; NUT21

Genomic context

See CCR4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (110846..113359, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT2 Neighboring gene nucleoside transmembrane transporter FUN26 Neighboring gene Ats1p Neighboring gene DNA-dependent ATPase FUN30

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
3'-5'-exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
3'-5'-exoribonuclease activity IGI
Inferred from Genetic Interaction
more info
PubMed 
3'-5'-exoribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
poly(A)-specific ribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication IGI
Inferred from Genetic Interaction
more info
PubMed 
DNA replication checkpoint IGI
Inferred from Genetic Interaction
more info
PubMed 
RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription elongation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
replication fork protection IGI
Inferred from Genetic Interaction
more info
PubMed 
transcription elongation from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
transcription elongation from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
traversing start control point of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
CCR4-NOT core complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with Cdc73/Paf1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
P-body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CCR4-NOT core exoribonuclease subunit CCR4
NP_009381.1
  • Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    110846..113359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178166.1NP_009381.1  TPA: CCR4-NOT core exoribonuclease subunit CCR4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009381.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31384
    Conserved Domains (4) summary
    COG5239
    Location:476837
    CCR4; mRNA deadenylase, 3'-5' endonuclease subunit Ccr4 [RNA processing and modification]
    sd00031
    Location:339358
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:359397
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:359438
    LRR_8; Leucine rich repeat
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