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PMT2 dolichyl-phosphate-mannose-protein mannosyltransferase PMT2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851210, updated on 22-Sep-2022

Summary

Gene symbol
PMT2
Gene description
dolichyl-phosphate-mannose-protein mannosyltransferase PMT2
Primary source
SGD:S000000021
Locus tag
YAL023C
See related
AllianceGenome:SGD:S000000021
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FUN25
Summary
Enables dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in cellular protein metabolic process; protein exit from endoplasmic reticulum; and regulation of endoplasmic reticulum unfolded protein response. Located in endoplasmic reticulum. Part of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex and dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex. Human ortholog(s) of this gene implicated in lissencephaly and muscular dystrophy (multiple). Orthologous to human POMT2 (protein O-mannosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PMT2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (106272..108551, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene ribosome biosynthesis protein MAK16 Neighboring gene mitotic regulator LTE1 Neighboring gene nucleoside transmembrane transporter FUN26 Neighboring gene CCR4-NOT core exoribonuclease subunit CCR4

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the PMT2 gene: The PMT2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.

Gene Ontology Provided by GO

General protein information

Preferred Names
dolichyl-phosphate-mannose-protein mannosyltransferase PMT2
NP_009379.2
  • Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; functions as a heterodimer with Pmt2p but can also pair with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    106272..108551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178168.1NP_009379.2  TPA: dolichyl-phosphate-mannose-protein mannosyltransferase PMT2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009379.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPJ5, P31382
    UniProtKB/TrEMBL
    A0A0L8VVW1, A0A8H4C1C4, B3LUV7, C7GPL2, C8Z3K4, H0GBX0, N1PAZ0
    Conserved Domains (1) summary
    COG1928
    Location:44757
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]