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CLN3 cyclin CLN3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851191, updated on 2-Oct-2018

Summary

Gene symbol
CLN3
Gene description
cyclin CLN3
Primary source
SGD:S000000038
Locus tag
YAL040C
Gene type
protein coding
RNA name
cyclin CLN3
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DAF1; FUN10; WHI1

Genomic context

See CLN3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (65778..67520, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Erv46p Neighboring gene Rho family guanine nucleotide exchange factor CDC24 Neighboring gene holocytochrome c synthase CYC3 Neighboring gene pyruvate kinase CDC19

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell Cycle and Cell Division, organism-specific biosystem (from WikiPathways)
    Cell Cycle and Cell Division, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
  • Cell cycle - G1/S transition, organism-specific biosystem (from KEGG)
    Cell cycle - G1/S transition, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Cell cycle - G1/S transition, conserved biosystem (from KEGG)
    Cell cycle - G1/S transition, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Cell cycle - yeast, organism-specific biosystem (from KEGG)
    Cell cycle - yeast, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
  • Cell cycle - yeast, conserved biosystem (from KEGG)
    Cell cycle - yeast, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
  • Meiosis - yeast, organism-specific biosystem (from KEGG)
    Meiosis - yeast, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
  • Meiosis - yeast, conserved biosystem (from KEGG)
    Meiosis - yeast, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein serine/threonine kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription involved in G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription involved in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
traversing start control point of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
traversing start control point of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
vacuole fusion, non-autophagic IDA
Inferred from Direct Assay
more info
PubMed 
vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
PubMed 
vacuole organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
cyclin CLN3
NP_009360.1
  • G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote G1 to S phase transition; plays a role in regulating transcription of other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; acetyl-CoA induces CLN3 transcription in response to nutrient repletion to promote cell-cycle entry; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    65778..67520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178185.1NP_009360.1  TPA: cyclin CLN3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009360.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P13365
    Conserved Domains (2) summary
    COG5024
    Location:35576
    COG5024; Cyclin [Cell division and chromosome partitioning]
    pfam00134
    Location:76206
    Cyclin_N; Cyclin, N-terminal domain
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