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CDC24 Rho family guanine nucleotide exchange factor CDC24 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851190, updated on 9-Jun-2019

Summary

Gene symbol
CDC24
Gene description
Rho family guanine nucleotide exchange factor CDC24
Primary source
SGD:S000000039
Locus tag
YAL041W
Gene type
protein coding
RNA name
Rho family guanine nucleotide exchange factor CDC24
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CLS4

Genomic context

See CDC24 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (62840..65404)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene RNA-processing protein PTA1 Neighboring gene Erv46p Neighboring gene cyclin CLN3 Neighboring gene holocytochrome c synthase CYC3

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rho guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemotropism IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
septin ring organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
septin ring organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Cdc24p-Far1p-Gbetagamma complex IDA
Inferred from Direct Assay
more info
PubMed 
Cdc24p-Far1p-Gbetagamma complex IPI
Inferred from Physical Interaction
more info
PubMed 
cell division site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular bud neck IDA
Inferred from Direct Assay
more info
PubMed 
cellular bud tip IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm HDA PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
division septum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
incipient cellular bud site IDA
Inferred from Direct Assay
more info
PubMed 
mating projection tip IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mating projection tip IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Rho family guanine nucleotide exchange factor CDC24
NP_009359.1
  • Guanine nucleotide exchange factor (GEF) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress; thermosensitivity of the cdc24-4 mutant in the presence of sorbitol is functionally complemented by human CDC42

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    62840..65404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178186.1NP_009359.1  TPA: Rho family guanine nucleotide exchange factor CDC24 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009359.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11433
    Conserved Domains (4) summary
    smart00325
    Location:282453
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    smart00666
    Location:779853
    PB1; PB1 domain
    cd13246
    Location:455667
    PH_Scd1; Shape and Conjugation Deficiency 1 Pleckstrin homology (PH) domain
    pfam06395
    Location:156242
    CDC24; CDC24 Calponin
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