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YRF1-4 Y' element ATP-dependent helicase protein 1 copy 4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851187, updated on 23-Apr-2026
Official Symbol
YRF1-4
Official Full Name
Y' element ATP-dependent helicase protein 1 copy 4
Primary source
SGD:S000004458
Locus tag
YLR466W
See related
AllianceGenome:SGD:S000004458; FungiDB:YLR466W; VEuPathDB:YLR466W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YRF1
Summary
Enables DNA helicase activity. Involved in telomere maintenance via recombination. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
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See YRF1-4 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (1067087..1071235)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene seripauperin PAU4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Y' element ATP-dependent helicase protein 1 copy 5

Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome-wide array-CGH analysis reveals YRF1 gene copy number variation that modulates genetic stability in distillery yeasts. Deregowska A, et al. Oncotarget, 2015 Oct 13. PMID 26384347, Free PMC Article
  2. A genetic screen for yeast genes induced by sustained osmotic stress. Runner VM, et al. Yeast, 2003 Jul 30. PMID 12868060
  3. Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. Yamada M, et al. J Biol Chem, 1998 Dec 11. PMID 9837911
  4. Targets of the cyclin-dependent kinase Cdk1. Ubersax JA, et al. Nature, 2003 Oct 23. PMID 14574415
  5. The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. Johnston M, et al. Nature, 1997 May 29. PMID 9169871, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in telomere maintenance via recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
Preferred Names
Y' element ATP-dependent helicase protein 1 copy 4
NP_013571.3
  • Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    1067087..1071235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182354.3 → NP_013571.3  Y' element ATP-dependent helicase protein 1 copy 4

    See identical proteins and their annotated locations for NP_013571.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ97, O13559
    Conserved Domains (3) summary
    COG0513
    Location:322 → 811
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:624 → 728
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:376 → 549
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O13559.1

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