SST2 GTPase-activating protein SST2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SST2
Official Full Name: GTPase-activating protein SST2
Primary source: SGD:S000004444
Locus tag: YLR452C
See related: AllianceGenome:SGD:S000004444; FungiDB:YLR452C; VEuPathDB:YLR452C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SSL2
Summary: Enables GTPase activator activity. Involved in cellular response to pheromone; conjugation with cellular fusion; and signal transduction. Located in plasma membrane. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to several human genes including RGS1 (regulator of G protein signaling 1); RGS13 (regulator of G protein signaling 13); and RGS16 (regulator of G protein signaling 16). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See SST2 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (1039270..1041366, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of RGS regulates MAP kinase localization and promotes completion of cytokinesis.
Title: Phosphorylation of RGS regulates MAP kinase localization and promotes completion of cytokinesis.
Results suggest that the G-protein-coupled receptor, Ste2 binds the inhibitory G-protein signaling, Sst2 forming a complex with antagonistic functions.
Title: Yeast GPCR signaling reflects the fraction of occupied receptors, not the number.
Results reveal that a regulator of G protein signaling can also regulate the G protein-coupled receptor. Whereas Sst2 negatively regulates G protein signaling, it acts in a positive manner to promote receptor retention at the growing edge.
Title: Modulation of receptor dynamics by the regulator of G protein signaling Sst2.
Sst2 limits variability in transcription and morphogenesis in response to pheromone stimulation.
Title: Cellular noise suppression by the regulator of G protein signaling Sst2.
These findings suggest that Sst2 is the principal regulator of Gpa1-mediated signaling in vivo but that other proteins also contribute in distinct ways to pathway regulation.
Title: Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae.
We demonstrate that DEP domains in Sst2 mediate binding to its cognate GPCR (Ste2). DEP-domain-mediated tethering promotes downregulation by placing the RGS protein in proximity to its substrate.
Title: DEP-domain-mediated regulation of GPCR signaling responses.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in response to pheromone	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: GTPase-activating protein SST2

NP_013557.1

GTPase-activating protein for Gpa1p; regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

1039270..1041366 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182340.1 → NP_013557.1 GTPase-activating protein SST2

See identical proteins and their annotated locations for NP_013557.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZ86, P11972, Q06207

UniProtKB/TrEMBL

A7A1X1, C7GSK6, G2WJR3, N1NZY8

Conserved Domains (3) summary

cd04450
Location:265 → 353

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

cl02442
Location:57 → 135

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

cl02565
Location:420 → 537

RGS; Regulator of G protein signaling (RGS) domain superfamily